| 1-[苯基(4-甲氧苯基亚胺基)甲基]-3-(1-萘基)硫脲的合成 |
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| 引用本文： | 邢志勇,于德成,李来军,刘海燕,张宇,于敏.1-[苯基(4-甲氧苯基亚胺基)甲基]-3-(1-萘基)硫脲的合成[J].精细化工中间体,2009,39(6):31-33,36. |
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| 作者姓名： | 邢志勇 于德成 李来军 刘海燕 张宇 于敏 |
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| 作者单位： | 1. 佳木斯大学药学院,黑龙江,佳木斯,154007;东北农业大学,理学院,黑龙江,哈尔滨,150030
2. 佳木斯大学药学院,黑龙江,佳木斯,154007 |
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| 基金项目： | 黑龙江省教育厅科学技术研究项目资助 |
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| 摘 要： | 以N-(4-甲氧基)苯基苯甲酰胺和二氯亚砜为原料,经氯代反应制得氯代4-甲氧基苯基苯甲酰亚胺(2),2与硫氰酸钠加成得中间体N-(异硫氰酸基(苯基)亚甲基)-4-甲氧基苯胺(3)后,与1-萘胺经加成反应合成得到最终产物1-(苯基(4-甲氧苯基亚胺基)甲基)-3-(1-萘基)硫脲(4),总收率为72.6%。合成化合物3的适宜工艺条件为:n(2)∶n(硫氰酸钠)=1∶1.2,丙酮为溶剂,反应温度为-15℃,反应时间3h。
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| 关 键 词： | 苯甲酰胺 二氯亚砜 硫氰酸钠 硫脲 |
Synthesis of 1-[(4-Methoxyphenylimino)phenylmethyl]-3-(naphth-alen-1-yl)thiourea |
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| XING Zhi-yong,YU De-chen,LI Lai-jun,LIU Hai-yan,ZHANG Yu,YU Min.Synthesis of 1-[(4-Methoxyphenylimino)phenylmethyl]-3-(naphth-alen-1-yl)thiourea[J].Fine Chemical Intermediates,2009,39(6):31-33,36. |
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| Authors: | XING Zhi-yong YU De-chen LI Lai-jun LIU Hai-yan ZHANG Yu YU Min |
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| Abstract: | The title compound 4 was prepared in several steps. Chlorinated compound, N-(4-methoxyphenyl) benzimidoyl chloride (2) was synthesized from N-(4-methoxyphenyl) benzamide and thionyl chloride. Addition of sodium thiocyanate to 2 followed by reaction with naphthylamine afforded the title compound in an overall yield of 72.6%. |
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| Keywords: | benzamide thionyl chloride sodium thiocyanate thiourea |
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