Synthesis,crystal structures and cytotoxic activity of mononuclear nickel(II) and dinuclear zinc(II) complexes with ligand derived from S-benzyldithiocarbazate |
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| Affiliation: | 1. Engineering Research Center of Functional Material Preparation, Shangqiu Normal University, Shangqiu, Henan 476000, PR China;2. State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, PR China;3. Department of Chemistry, Nankai University, Tianjin 300071, PR China;1. Department of Chemistry and Key Laboratory of Advanced Energy Materials Chemistry (MOE), Nankai University, Tianjin 300071, China;2. State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China;1. Department of Chemistry, Centre for Advance Studies in Chemistry, North Eastern Hill University, Shillong 793022, Meghalaya, India;2. Departement of Chemistry, Centre of Advanced Study, Banaras Hindu University, Varanasi 221005, India;3. Department of Chemistry, Faculty of Science and Agriculture, The University of West-Indies, St. Augustine, Trinidad and Tobago;1. Chemistry Department, Deanery of Academic Services, Taibah University, Yanbu Branch, Yanbu El-Bahr, Saudi Arabia;2. Department of Chemistry, Faculty of Science, Mansoura University, Mansoura 35516, Egypt |
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| Abstract: | 
Ni(L)2 (1) and Zn2(μ-OL)2(L)2 (2), (HL = S-benzyl-β-N-(2-bromobenzylidene) dithiocarbazate), were synthesized and characterized by elemental analysis and X-ray single-crystal diffraction analysis. 1 is a mononuclear neutral nickel(II) complex and the center nickel atom is chelated by donors of N2S2 possessing a distorted tetrahedral configuration, while in 2, the adjacent two complex molecules are linked through two O atoms to form a dimer and the center zinc atom is five-coordinate in a distorted trigonal–bipyramidal geometry. The cytotoxic activity study indicated that 2 showed potent cytotoxic activity against the human liver hepatocellular carcinoma (HepG2) cancer cell lines, with IC50 2.4 ± 0.2 μg·mL− 1, which is slightly weaker than 5-fluoroacil (5-FU) (0.89 ± 0.21 μg·mL− 1) as reference. A gel electrophoresis assay demonstrated the ability of the complex to cleave the pBR322 plasmid DNA. |
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