钠-葡萄糖共转运体2抑制剂在治疗2型糖尿病中的应用

糖尿病患者需要长期应用降糖药物控制血糖及防止并发症,因此研发疗效好、不良反应少的降糖药物尤为重要。钠-葡萄糖共转运体2(SGLT2)抑制剂为近些年来研究较多的一种用于2型糖尿病的新药物,有望在糖尿病患者的治疗中取得良好的效果。本文对该类药物的发展过程、代表药物、药理作用及不良反应等方面进行综述。

SGLT2 inhibitor for the treatment of type 2 diabetes mellitus

Since the diabetic patients need to use anti-diabetic drugs to control serum glucose level and prevent complications for a long time, it's very important to discover a kind of drug which not only have good effect but also have less adverse drug reactions. In recent years,the SGLT2 inhibitor is well developed as a new kind of drug for type 2 diabetes, and is hopeful to acquire good therapeutic effect on diabetic patients. In this article we mainly describe the history, represent drugs, pharmacological effects and adverse reactions of this kind of drugs.