| N-乙基-2,3-二氧代哌嗪的合成 |
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| 引用本文： | 许建帼,谢建伟,吴敏,邵丽莉.N-乙基-2,3-二氧代哌嗪的合成[J].精细化工中间体,2005,35(4):18-19. |
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| 作者姓名： | 许建帼 谢建伟 吴敏 邵丽莉 |
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| 作者单位： | 1. 浙江工业大学,浙西分校化工系,浙江,衢州,324006
2. 浙江巨化技术中心,浙江,衢州,324004 |
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| 摘 要： | 以N-乙基乙二胺和草酸二乙酯为原料,在氯化胺催化作用下脱醇缩合得N-乙基-2,3-二氧代哌嗪。实验研究了反应物摩尔配比、反应时间、反应温度、催化剂用量等对N-乙基-2,3-二氧代哌嗪收率影响,得出了优惠工艺条件:催化剂用量为N-乙基乙二胺质量的1.5%,原料草酸二乙醇与N-乙基乙二胺摩尔比为1.02∶1,反应温度为20℃,乙酸用量200mL。总收率达到85%。
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| 关 键 词： | N-乙基乙二胺 N-乙基-2 3-二氧代哌嗪 哌拉西林 |
| 文章编号： | 1009-9212(2005)04-0018-02 |
| 收稿时间： | 2005-03-02 |
| 修稿时间： | 2005年3月2日 |
Synthesis of N-ethyl-2,3-dioxopiperazine |
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| XU Jian-guo,XIE Jian-Wei,WU Ming,SHAO Li-li.Synthesis of N-ethyl-2,3-dioxopiperazine[J].Fine Chemical Intermediates,2005,35(4):18-19. |
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| Authors: | XU Jian-guo XIE Jian-Wei WU Ming SHAO Li-li |
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| Abstract: | N-ethyl-2,3-dioxopiperazine was synthesized from N-ethylethylenediamine and diethyl ethanedioate by condensation reaction with catalyst ammonia chloride .The effects of mole ratios , reaction time, temperature and the amount of catalyst on the yields of N-ethyl-2,3-dioxopiperazine were investigated .The optimal condition was as follows:w(cat)=1.5%(N-alkylethylenediamin),n(diethylethanedioate):n(N-alkylethylenediamine)=1.02∶1,reaction temperature 20℃,ethanol zooml,The yield of N-ethy1-2,3-dioxopipevazine was more than 85%? |
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| Keywords: | N-ethyl-2 3- dioxopiperazine N-alkylethylenediamine Piperacillin |
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