| 氨噻肟酸的合成 |
| |
| 引用本文： | 徐娟娟,胡艾希.氨噻肟酸的合成[J].精细化工,2007,24(4):385-386,396. |
| |
| 作者姓名： | 徐娟娟 胡艾希 |
| |
| 作者单位： | 1. 湖南大学,化学化工学院,湖南,长沙,410082
2. 湖南大学,化学化工学院,湖南,长沙,410082;华南理工大学,化工与能源学院,广东,广州,510640 |
| |
| 摘 要： | 4-氯乙酰乙酸乙酯经亚硝酸异丙酯肟化、硫脲环合一步反应制得去甲氨噻肟酸乙酯。反应条件为:n(4-氯乙酰乙酸乙酯)∶n(亚硝酸异丙酯)=1∶1.05,肟化反应温度为10~12℃,肟化反应、环合反应时间分别为22、3.5h。去甲氨噻肟酸乙酯经甲基化、水解反应后得到氨噻肟酸,总收率46.3%(以4-氯乙酰乙酸乙酯计)。产物经1HMNR表征,符合结构特征。
|
| 关 键 词： | 氨噻肟酸 4-氯乙酰乙酸乙酯 肟化反应 |
| 文章编号： | 1003-5214（2007）04-0385-03 |
| 修稿时间： | 2006-10-142006-11-13 |
Synthesis of 2-(2-Aminothiazole-4-yl)-2-(Z)-methoxyiminoacetic Acid |
| |
| XU Juan-juan,HU Ai-xi.Synthesis of 2-(2-Aminothiazole-4-yl)-2-(Z)-methoxyiminoacetic Acid[J].Fine Chemicals,2007,24(4):385-386,396. |
| |
| Authors: | XU Juan-juan HU Ai-xi |
| |
| Affiliation: | 1. College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, Hunan, China;2. School of Chemical and Energy Engineering, South China University of Technology, Guangzhou 510640, Guangdong, China |
| |
| Abstract: | Ethyl 4-chloroacetoacetate was oximated with isopropyl nitrite and then condensated with thiourea to give ethyl 2-(2-aminothiazole-4yl)-2-hydroxyiminoacetic acid.Mole ratio of ethyl 4-chloroacetoacetate and isopropyl nitrite was 1∶1.05,reaction temperature of oximation was 10～12 ℃,and reaction time of oximation and condensation were 22 h and 3.5 h,respectively.The ester was converted into 2-(2-aminothiazole-4-yl)-2-(Z)-methoxyiminoacetic acid via methylation and hydrolyzation.The total yield was 46.3 %(based on ethyl 4-chloroacetoacetate).Structures of the products were confirmed by 1HNMR. |
| |
| Keywords: | 2-(2-aminothiazole-4-yl)-2-(Z)-methoxyiminoacetic acid ethyl 4-chloroacetoacetate oximation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
