Selective inhibition of the duck hepatitis B virus by a new class of tetraazamacrocycles |
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| Authors: | O Hantz C Borel C Trabaud F Zoulim J Dessolin M Camplo P Vlieghe M Bouygues C Trepo JL Kraus |
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| Affiliation: | Unité de Recherche sur les Hépatites, le SIDA et les Rétrovirus Humains, Institut National de la Santé et de la Recherche Médicale U271, Lyon, France. hantz@lyon151.inserm.fr |
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| Abstract: | ![]()
The antiviral activity of a new class of N,N,N',N",NA'-pentakis (omega-aminoalkyl) tetraazamacrocycles was evaluated in primary duck hepatocyte cultures infected with the duck hepatitis B virus (DHBV). Three of the four tested compounds were able to selectively inhibit DHBV replication by acting at an early step of the hepadnavirus infection but were associated with significant toxicity. |
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