Knitted Silk Fibroin‐Reinforced Bead‐on‐String Electrospun Fibers for Sustained Drug Delivery Against Colon Cancer |
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| Authors: | Panpan Ma Shuangquan Gou Min Wang Jiucun Chen Wei Hu Bo Xiao |
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| Affiliation: | 1. State Key Laboratory of Silkworm Genome Biology, Southwest University, Beibei, Chongqing, P. R. China;2. Institute for Clean Energy and Advanced Materials, Faculty of Materials and Energy, Southwest University, Beibei, Chongqing, P. R. China;3. College of Life Science and Chemistry, Wuhan Donghu University, Wuhan, Hubei, P. R. China |
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| Abstract: | Bead‐on‐string electrospun fibers containing camptothecin (CPT) are fabricated on the surface of knitted silk fibroin (SF) meshes. Microscopic characterization reveals that the bead‐on‐string structure is prepared successfully and CPT is mainly located within the beaded structure. Interestingly, the CPT‐loaded beaded SF mesh (CPT‐SF mesh) has excellent mechanical properties. More importantly, it is able to perform a sustained CPT release without burst release. In vitro cytotoxicity tests further indicate that the CPT‐SF mesh shows much stronger anticolon cancer activity in comparison with SF meshes and beaded SF meshes. Hence, the CPT‐SF mesh has great potential as a promising local drug delivery system for colon cancer treatment. |
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| Keywords: | bead‐on‐string biofibers colon cancer localized chemotherapy silk fibroin |
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