The effect of DNA probe distribution on the reliability of label-free biosensors |
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| Authors: | MW Shinwari MF Shinwari MJ Deen PR Selvaganapathy[Author vitae] |
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| Affiliation: | aElectrical and Computer Engineering, 1280 Main St. West, Hamilton, ON L8S 4K1, Canada;bCrimson Fusion, P.O. Box 3760, Al-Khobar 31952, Saudi Arabia;cMechanical Engineering, McMaster University, 1280 Main St. West, Hamilton, ON L8S 4K1, Canada |
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| Abstract: | As the design of label-free DNA biosensors matures, and their sizes reduced to enhance their sensitivity, not much has been researched about the variations in the received signal with the positioning of the probes on the sensitive surface. We approach this issue computationally in this paper. By adopting the finite-element model on a three-dimensional biological field-effect transistor (BioFET) slice, and running Monte-Carlo simulations on the positions of the DNA molecules, we extract the expected variations in the signal. Then, we show that signal-to-noise (SNR) ratio can be low enough to hinder the functionality of the device, placing a limitation on how low the sensitivity of a sensor of a certain size can be. |
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| Keywords: | Biosensor DNA Finite-element Lab-on-chip Label-free Simulation |
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