Gold nanoparticle film grown on quartz fiber and its application as a microsensor of nitric oxide |
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| Authors: | Xueping Dang Chengguo Hu Yingkai Wang Shengshui Hu[Author vitae] |
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| Affiliation: | aKey Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Luojia Hill No. 26, Wuhan 430072, PR China;bCollege of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, PR China;cState Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Beijing 10080, PR China |
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| Abstract: | A simple electroless plating method for growing a gold nanoparticle (GNP) film on a quartz fiber by chemical liquid deposition was reported. The gold film coated quartz fiber possessed good conductivity and mechanical property, and can be used as a novel gold fiber microelectrode (GFME). Being electropolymerized with niacinamide (NA) and further coated by Nafion for GFME, a disposable nitric oxide (NO) electrochemical microsensor was fabricated. This microsensor exhibited high sensitivity based on the catalytic effect of GNPs and polyniacinamide (PNA) toward the oxidation of NO. A good linear relationship between the amperometric response of the microsensor and the concentration of NO in the range of 7.2 × 10−9–1.8 × 10−5 mol L−1 was achieved, along with a low detection limit of 3.6 nmol L−1 (S/N = 3). In vivo detection of NO release from mice liver indicated that this microsensor had a promising application in the field of biomedical analysis. |
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| Keywords: | Quartz fiber Gold nanoparticles Niacinamide Nitric oxide Electrochemical microsensor |
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