酸枣仁提取物、龙眼肉提取物、γ-氨基丁酸和酪蛋白水解物复配制剂改善睡眠功能

本文通过直接睡眠实验、延长戊巴比妥钠睡眠时间实验、戊巴比妥钠阈下剂量催眠实验以及巴比妥钠睡眠潜伏期实验,研究了酸枣仁提取物、龙眼肉提取物、γ-氨基丁酸和酪蛋白水解物复配制剂对小鼠睡眠的改善效果。实验选取48只小鼠作为研究对象,随机分成对照组、高、中、低剂量组,灌胃复配制剂4周后,测定相应指标。结果显示,该复配制剂在高、中、低三个剂量下均可显著延长戊巴比妥钠诱导的小鼠睡眠时间,高剂量组睡眠时间为3793±1100 s,中剂量组睡眠时间为3591±1589 s,低剂量组睡眠时间为3218±582 s,而对照组的睡眠时间仅为1556±686 s。复配制剂的高中低剂量组均可缩短巴比妥钠催眠小鼠的入睡潜伏期,入睡潜伏期分别为171±58 s、165±40 s和184±52 s,对照组的入睡潜伏期为300±155 s。复配制剂所有剂量组均对直接睡眠无明显作用,对小鼠体重均无显著性影响。

The Study of Improvement in Sleep Function with Compounded Formulations of Ziziphus jujuba Extract,Longan Lour Extract, γ-Amino Butyric Acid,and Casein Hydrolysate

In this paper, through the direct sleep experiment, the experiment of prolonging the sleep time of pentobarbital sodium, the hypnosis experiment of subthreshold dose of pentobarbital sodium and the sleep latency experiment of pentobarbital sodium, the effects of compound preparations of Ziziphus jujuba extract, longan lour extract, γ-amino butyric acid and casein hydrolysate on sleep improvement in mice were studied. Experiment selected 48 mice as the research object, were randomly divided into control group, high, medium and low dose group, gavage compound preparation after 4 weeks, and the corresponding indicators were measured. The results showed that the compound preparation could significantly prolong the sleep time of mice induced by pentobarbital sodium at high, medium and low doses. The sleep time of the high dose group was 3793±1100 s, the sleep time of the medium dose group was 3591±1589 s, and the sleep time of the low dose group was 3218±582 s, while the sleep time of the control group was only 1556±686 s. The sleep latency of mice hypnotized by barbital sodium was shortened in the high-dose, middle-dose and low-dose compound preparations. The sleep latency was 171±58 s, 165±40 s and 184±52 s respectively. The sleep latency of the control group was 300±155 s. All dose groups of the compound preparation had no significant effect on direct sleep and no significant effect on the body weight of mice.