D-甘露糖生产工艺及生理功能研究进展

D-甘露糖为D-葡萄糖的C-2位差向异构体,生产方法包括植物提取法、化学合成法和生物转化法三种,其中生物转化法受到越来越多的关注。D-甘露糖已经被发现具有多种重要的生理功能,一方面D-甘露糖可以通过阻止细菌粘附尿路上皮达到泌尿系统保护作用;二是D-甘露糖可以通过干扰葡萄糖代谢、转运以及修饰抗癌药物载体起到抗肿瘤作用;三是通过增强初始T细胞向调节性T细胞（Treg细胞）转化起到免疫系统调节作用。未来D-甘露糖的生理功能需要更多研究数据进一步证实,以期为D-甘露糖在功能性食品和生物医药方面的应用提供支持。本文就D-甘露糖的生产工艺、代谢途径、生理功能及应用等方面的研究进展进行综述。

Research Progress on the Production Technology and Physiological Function of D-mannose

D-mannose is the C-2 epimer of D-glucose. The production methods of D-mannose include plant extraction, chemical synthesis, and biotransformation. In particular, the biotransformation method has received more and more attention. D-mannose has been found to have a variety of important physiological functions. On the one hand, D-mannose can protect the urinary system by preventing bacteria from adhering to the urothelium. On the other hand, D-mannose can interfere with glucose metabolism, transport and modified anti-cancer drug carriers play an anti-tumor effect. In addition, D-Mannose can regulate the immune system by enhancing the transformation of naive T cells into regulatory T cells (Treg cells). In the future, the physiological functions of D-mannose need to be further confirmed by more research data, in order to provide support for the application of D-mannose in functional foods and biomedicine. This review introduces the recent progress of studies on the production technology, metabolic pathways, physiological functions and application of D-mannose.