| 含二茂铁基1,2,4-三唑化合物的合成及其抗真菌活性 |
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| 引用本文： | 高学祥,王嫚,刘栋,花成文,苟小锋.含二茂铁基1,2,4-三唑化合物的合成及其抗真菌活性[J].广东化工,2014(2):5-6,24. |
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| 作者姓名： | 高学祥 王嫚 刘栋 花成文 苟小锋 |
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| 作者单位： | 西北大学化学与材料科学学院,合成与天然功能分子化学教育部重点实验室,陕西西安710069 |
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| 基金项目： | 陕西省自然科学基金资助项目（NO：96H06） |
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| 摘 要： | 以二茂铁为起始原料,通过一系列反应合成二茂铁二甲酰氯中间体;以酸或者苯氧乙酸为起始原料,合成中间体1,2,4-三唑化合物,最后二茂铁二甲酰氯与1,2,4-三唑化合物反应,生成含二茂铁基1,2,4-三唑化合物。通过1H-NMR、FT-IR及ESI-HRMS进行了目标化合物结构的表征;最后,将合成的目标化合物分别对小麦赤霉病、马铃薯干腐病、烟草赤星病和西瓜枯萎病进行了初步的抗植物真菌活性试验,测试结果显示,部分化合物表现出较好的抗植物真菌活性。
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| 关 键 词： | -三唑 二茂铁 抑菌活性 合成 |
Synthesis and Antifungal Activity of 1,2,4-Triazoles Containing Ferrocenyl |
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| Gao Xuexiang,Wang Man,Liu Dong,Hua Chengwen,Gou Xiaofeng.Synthesis and Antifungal Activity of 1,2,4-Triazoles Containing Ferrocenyl[J].Guangdong Chemical Industry,2014(2):5-6,24. |
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| Authors: | Gao Xuexiang Wang Man Liu Dong Hua Chengwen Gou Xiaofeng |
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| Affiliation: | (Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi＇an 710069, China) |
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| Abstract: | A series of 1,2,4-triazoles containing ferrocenyl were designed and synthesized from Chlorocarbonyl ferrocene and 1,2,4-triazole. The structures of the title compounds were confirmed by I H-NMR, FT-IR and ESI-HRMS. Finally, the primary antimycotic activity of the target compounds against four plant fungals （Gibberlla saubinetii, Pythium solani, Gibberlla nicotiancola, Fusarium oxysporium f.s.p, niveum.） had been screened. The final results indicate that some of the compounds have a good plant anti-fungal activity. |
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| Keywords: | 1 2 4-triazoles： ferrocene antifungalactivity： synthesis |
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