3-环己基丙酸的合成

以丙烯酸甲酯和环己醇为原料,经过酯交换反应合成γ,γ-环戊基丁内酯,γ,γ-环戊基丁内酯加氢得到3-环己基丙酸。考察了2步反应的催化剂和反应条件对产物收率的影响。研究结果表明,酯交换反应的优化条件为:过氧化二叔丁基为引发剂,n(丙烯酸甲酯)∶n(环己醇)=1∶4,反应温度160℃,反应时间6 h;在该条件下,γ,γ-环戊基丁内酯的收率可达93.3%;以0.5%铅/氧化铝为催化剂,γ,γ-环戊基丁内酯加氢反应的优化条件为:反应温度为250℃,γ,γ-环戊基丁内酯空速0.2 h-1,反应压力3.0 MPa,氢气空速500 h-1,在该条件下,γ,γ-环戊基丁内酯转化率78.0%,环己基丙酸选择性80.2%。

Synthesis of 3-Cyclohexylpropionic Acid

3-Cyclohexylpropionic acid was prepared by hydrogenation of γ,γ-cyclopentyl butyrolactone,which was synthesized by transesterification of methyl acrylate and cyclohexanol.The influences of catalyst and reaction conditions have been studied.The optimum conditions for the transesterification include the temperature of 160℃,the molar ratio of methyl acrylate to cyclohexanol of 1 to 4,the reaction time of 6 hours and di-tert-butyl peroxide as the initiator.Over the catalyst of 0.5%Pd/Al2O3,the conversion of γ,γ-cyclopentyl butyrolactone and the selectivity of 3-cyclohexylpropionic acid can reach 78.0% and 80.2%,respectively,under the optimum condition of 250℃,3.0 MPa,LHSV of γ,γ-cyclopentyl butyrolactone of 0.2 h-1 and GHSV of H2 of 500 h-1.