| 5-硝基靛红衍生物的合成 |
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| 引用本文： | 颜耘,赵萍,孙广龙,詹晓平,毛振民.5-硝基靛红衍生物的合成[J].精细化工中间体,2011,41(5):32-34. |
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| 作者姓名： | 颜耘 赵萍 孙广龙 詹晓平 毛振民 |
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| 作者单位： | 上海交通大学药学院,上海,200240 |
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| 基金项目： | 综合性新药研究开发技术大平台(2009ZX09301-007) |
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| 摘 要： | 以靛红为原料,经过硝化和亲核取代,合成了3个N取代5-硝基靛红衍生物,其结构经1H NMR、13C NMR、MS分析确认。
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| 关 键 词： | N-烷基-5-硝基 靛红衍生物 caspase-3抑制剂 合成 |
Synthesis of Novel 5-nitroisatin Derivatives |
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| YAN Yun,ZHAO Ping,SUN Guang-long,ZHAN Xiao-ping,MAO Zhen-min.Synthesis of Novel 5-nitroisatin Derivatives[J].Fine Chemical Intermediates,2011,41(5):32-34. |
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| Authors: | YAN Yun ZHAO Ping SUN Guang-long ZHAN Xiao-ping MAO Zhen-min |
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| Affiliation: | YAN Yun1,ZHAO Ping2,SUN Guang-long2,ZHAN Xiao-ping2,MAO Zhen-min1,2 (School of Pharmacy,Shanghai Jiaotong University,Shanghai 200240,China) |
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| Abstract: | Isatin and its derivatives which have certain biological activities are important pharmaceutical intermediates and drug candidates.Three novel N-alkylated-5-nitroisatin derivatives were syn-thesized from isatin by nitration and nucleophilic substitution.The structures were identified by 1HNMR,13CNMR and MS. |
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| Keywords: | N-alkylated-5-nitroisatin isatin derivatives caspase-3 inhibitors synthesis |
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