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| 1-羟基-4-(4-甲基苯基)-2-甲肟基咪唑-3-氧化物的合成工艺研究 | |
| 引用本文： | 朱丽超,黄超群,庞怀林,兰支利,陶贤鉴.1-羟基-4-(4-甲基苯基)-2-甲肟基咪唑-3-氧化物的合成工艺研究[J].精细化工中间体,2011,41(4):31-33. |
| 作者姓名： | 朱丽超 黄超群 庞怀林 兰支利 陶贤鉴 |
| 作者单位： | 1. 湖南师范大学化学化工学院,湖南长沙410081;湖南化工研究院国家农药创制工程技术研究中心,湖南长沙410007;农用化学品湖南省重点实验室,湖南长沙410007 2. 湖南化工研究院国家农药创制工程技术研究中心,湖南长沙410007;农用化学品湖南省重点实验室,湖南长沙410007 3. 湖南师范大学化学化工学院,湖南长沙,410081 |
| 摘 要： | 以2,2-二氯-4'-甲基苯乙酮为原料,在六水合氯化铁促进下,与羟胺盐和乙二醛反应,得到1-羟基-4-(4-甲基苯基)-2-甲肟基咪唑-3-氧化物。研究了反应时间、物料配比、溶剂的种类和三氯化铁的用量等因素对环化反应的影响,优惠条件下的收率达到87.5%。该法原料来源广、成本低、反应条件温和、收率高,具有工业化应用前景。 |
| 关 键 词： | 1-羟基-4-(4-甲基苯基)-2-甲肟基咪唑-3-氧化物 环化反应 氰霜唑 合成 |
Study on the Synthesis of 1-Hydroxy-4-(4-methylphenyl)-2-oxyiminomethylimidazole-3-oxide |
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| ZHU Li-chao,HUANG Chao-qun,PANG Huai-lin,LAN Zhi-li,TA Xian-jian.Study on the Synthesis of 1-Hydroxy-4-(4-methylphenyl)-2-oxyiminomethylimidazole-3-oxide[J].Fine Chemical Intermediates,2011,41(4):31-33. | |
| Authors: | ZHU Li-chao HUANG Chao-qun PANG Huai-lin LAN Zhi-li TA Xian-jian |
| Affiliation: | ZHU Li-chao1,2,3,HUANG Chao-qun2,3*,PANG Huai-lin2,LAN Zhi-li1,TAO Xian-jian2,3(1.College of Chemistry and Chemical Engineering,Hunan Normal University,Changsha 40081,China,2.National Enigineering Research Center for Agrochemicals,Hunan Research Institute of Chemical Industry,Changsha 410007,3.Hunan Province Key Laboratory for Agrochemicals,China) |
| Abstract: | 1-Hydroxy-4-（4-methylphenyl）-2-oxyiminomethylimidazole-3-oxide was prepared under the promotion of FeCl3O·6H2O through a glyoxal reaction using 2,2-dichloro-4＇-methyl acetophenone with hydroxylamine salt.The effect of reaction time,material ratio and solvent types on the cyclization reaction was discussed,with a yield of 87.5% under an optimized condition.This method has various advantages,such as rich source of the readily available raw materials,low cost,mild reaction conditions and high yield,and it has a good prospect for industrialization. |
| Keywords: | 1-hydroxy-4-(4-methylphenyl)-2-oxyiminomethylimidazole-3-oxide cyclization Cyazofamid synthesis |
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