| 固体光气法合成2-氧-5-甲基-3-氢-1,3,4一噁二唑 |
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| 引用本文： | 徐强,张华,李亚明,卜鑫宇,韩彦丽,袁晶.固体光气法合成2-氧-5-甲基-3-氢-1,3,4一噁二唑[J].化学试剂,2005(4). |
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| 作者姓名： | 徐强 张华 李亚明 卜鑫宇 韩彦丽 袁晶 |
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| 作者单位： | 大连理工大学精细化工国家重点实验室 辽宁大连116012
(徐强，张华，李亚明，卜鑫宇，韩彦丽)，大连理工大学精细化工国家重点实验室 辽宁大连116012(袁晶) |
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| 摘 要： | 研究了以乙酸乙酯为原料,用固体光气代替光气合成2-氧-5-甲基-3-氢-1,3,4-(口恶)二唑,为该中间体的合成提供了一条环境友好的新途径。考察了反应温度、反应物配比、反应溶剂等因素对收率的影响,在最佳条件下,合成总收率为81.8%。目标化合物经红外光谱、核磁共振谱、质谱验证。
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| 关 键 词： | 乙酸乙酯 固体光气 2-氧-5-甲基-3-氢-1 3 4-噁二唑 合成 |
Synthesis of 2-oxo-5-methyl-3-hydro-1, 3, 4-osadiazol by tnphosgene |
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| XU Qiang,ZHANG Hua,LI Ya-ming,BU Xin-yu,HAN Yan-li,YUAN Jing.Synthesis of 2-oxo-5-methyl-3-hydro-1, 3, 4-osadiazol by tnphosgene[J].Chemical Reagents,2005(4). |
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| Authors: | XU Qiang ZHANG Hua LI Ya-ming BU Xin-yu HAN Yan-li YUAN Jing |
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| Abstract: | A method of synthesis for 2-oxo-5-methyl-3-hydro-1 , 3,4-osadiazol from ethyl acetate,replacing phosgene with triphos gene, provided a novel environmentally-friendly approach for the synthesis of 2-oxo-5-methyl-3-hydro-1, 3,4-osadiazol, which was a key pesticide intermediate. The effects of reaction temperature, reactant ratio and solvent on this reaction were investigated. Under optimum conditions the total yield of 2-oxo-5-methyl-3-hydro-1,3,4-osadiazol was up to 81 .8% .The title compound was identified by FT-IR,MS and NMR. |
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| Keywords: | ethyl acetate triphosgene 2-oxo-5-methyl-3-hydro-1 3 4-osadiazol synthesis |
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