Synthesis and hypoxia-selective cytotoxicity of a 2-nitroimidazole mustard |
| |
| Authors: | HH Lee BD Palmer WR Wilson WA Denny |
| |
| Affiliation: | Auckland Cancer Society Research Centre, New Zealand. |
| |
| Abstract: | A four-step synthesis of 5-[N,N-bis(2-chloroethyl)amino]-1-methyl-2-nitroimidazole from 1-methyl-2-nitroimidazole is described. This compound showed similar hypoxia-selective cytotoxicity to the dinitrobenzamide mustard SN 23,862 in UV4 cells (ca. 40-fold), and superior selectivity (> 7-fold) in repair-competent AA8 cells. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
