| 丙型肝炎病毒F蛋白在病毒复制和致病中的作用 |
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| 引用本文： | 王文博,任浩.丙型肝炎病毒F蛋白在病毒复制和致病中的作用[J].粉末涂料与涂装,2011,24(3):349-353. |
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| 作者姓名： | 王文博 任浩 |
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| 作者单位： | 第二军医大学微生物学教研室全军生物侦检与防护重点实验室上海市医学生物防护重点实验室; |
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| 基金项目： | 军队“十一五”医药卫生科研基金(06Z027,06H021); 国家自然科学基金(30872247,30600529); 上海市重点学科(B901); 第二军医大学“优秀硕士研究生苗子培育基金”(校研[2010]90号) |
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| 摘 要： | 丙型肝炎病毒(Hepatitis C virus,HCV)属于黄病毒科,是有包膜的单正链RNA病毒.HCV基因组约有9 600个碱基,编码的单一开放读码框(Open reading frame,ORF)翻译出约3 000个氨基酸残基的多聚蛋白前体,在宿主细胞及病毒蛋白酶的作用下,剪切成至少10种结构蛋白和非结构蛋白.近...
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| 关 键 词： | 丙型肝炎病毒 F蛋白 重叠读码框 核糖体漂移 病毒复制 毒力 |
Role of Hepatitis C Virus F Protein in Virus Replication and Pathogenesis |
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| WANG Wen-bo,REN Hao.Role of Hepatitis C Virus F Protein in Virus Replication and Pathogenesis[J].Chinese Journal of Biologicals,2011,24(3):349-353. |
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| Authors: | WANG Wen-bo REN Hao |
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| Affiliation: | WANG Wen-bo,REN Hao(Department of Microbiology,The Second Military Medical University,Key Laboratory of Biodetection and Biodefense of PLA,Shanghai Key Laboratory of Medical Biodefense,Shanghai 200433,China) |
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| Abstract: | Hepatitis C virus(HCV) is an enveloped positive-strand RNA virus of the Flaviviridae family,of which the genome consists of about 9 600 nucleotides encoding a polyprotein(about 3 000 amino acids) that is processed by cellular and viral proteases into at least ten structural and nonstructural viral proteins.In recent years,a novel HCV protein has been identified by several laboratories,known as the reading frame shift protein(alternative reading frame protein,ARFP) or F protein(frameshift protein),also calle... |
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| Keywords: | Hepatitis C virus(HCV) F protein Overlapping reading frame Ribosomal drift Virus replication Virulence |
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