| R-3,5-(双三氟甲基)苯乙醇不对称合成工艺 |
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| 引用本文： | 蒲国荣,周龙昌,向忠权,孙果宋,韦志明,陈小鹏.R-3,5-(双三氟甲基)苯乙醇不对称合成工艺[J].精细化工,2013(4):468-470. |
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| 作者姓名： | 蒲国荣 周龙昌 向忠权 孙果宋 韦志明 陈小鹏 |
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| 作者单位： | 广西大学化学化工学院;广西化工研究院 |
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| 摘 要： | 以RuCl2(C10H14)2]2为催化剂、(1S,2R)-(-)-1-氨基-2-茚醇为配体,3,5-双三氟甲基苯乙酮在异丙醇中发生不对称氢化还原反应得到R-3,5-(双三氟甲基)苯乙醇。在反应时间6 h、温度50℃、n(催化剂)∶n(配体)=1∶2.5、底物浓度0.095 7 mol/L的条件下,产品的转化率达99.32%,选择性(ee)达91.2%。用FTIR和1HNMR进行了表征。
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| 关 键 词： | 3 5-双三氟甲基苯乙酮 不对称合成 R-3 5-(双三氟甲基)苯乙醇 精细化工中间体 |
Asymmetric Synthesis of R-3,5(Trifluoro-dimethyl) Benzene Ethanol |
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| PU Guo-rong,ZHOU Long-chang,XIANG Zhong-quan,SUN Guo-song,WEI Zhi-ming,CHEN Xiao-peng.Asymmetric Synthesis of R-3,5(Trifluoro-dimethyl) Benzene Ethanol[J].Fine Chemicals,2013(4):468-470. |
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| Authors: | PU Guo-rong ZHOU Long-chang XIANG Zhong-quan SUN Guo-song WEI Zhi-ming CHEN Xiao-peng |
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| Affiliation: | 1(1.College of Chemistry and Chemical Engineering,Guangxi University,Nanning 530004,Guangxi,China;2.Guangxi Research Institute of Chemical Industry,Nanning 530001,Guangxi,China) |
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| Abstract: | An asymmetric transfer hydrogenation was adopted to synthesize R-3,5-(trifluoro-dimethyl) benzene ethanol from 3,5-bis(trifluoromethyl)acetophenone in isopropyl alcohol by using RuCl2(C10H14)2]2 as catalyst and(1S,2R)-(-)-1-amino-2-indene alcohol as ligands.When the reaction time was 6 h,reaction temperature was 50 ℃,catalyst/ligands molar ratio was 1∶ 2.5,and the substrate concentration was 0.095 7 mol/L,the conversion rate of the product was 99.32%,and selectivity(ee) was 91.2%.The target product was characterized by means of FTIR and 1HNMR. |
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| Keywords: | 3 5-bis(trifluoromethyl)acetophenone asymmetric synthesis R-3 5(trifluoro-dimethyl) benzene ethanol fine chemical intermediates |
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