Physical Aspects of Wet Granulation IV - Effect of Kneadign time on Dissolution Rates and Tablet Properties |
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Authors: | K. D. Brtel M. A. Zoglio W. A. Ritschel J. T. Carstensen |
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Affiliation: |
a Merrell Dow Research Institute Clincinnati, OH
b Merrell Dow Research Institue Institute Cincinnati, OH
c College of Pharmacy, University of Cinicinnati Meidal Center Cinicnnati, OH
d School of Pharmacy, Univeristiy of Wisconsion Madison, WI |
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Abstract: | The phsical properties of sucrose-lactoes-strach granulations containing a water soluble drug are characterized, and the relationship between granulaion kneading time and each of the these properties is examined. In addition, the effect of granulation kneading time on the properties of tablets prepared from the granules is examined. |
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