人参茎叶皂甙对5-氟脲嘧啶抗肿瘤的增强作用

目的: 观察人参茎叶皂甙(GSL) 促进氟脲嘧啶( 5-FU) 对小鼠S180 实体瘤的抑瘤作用。方法: 采用昆明种小鼠, 随机分组进行实验, 分别给予不同剂量人参茎叶皂甙与氟脲嘧啶配伍使用, 观察其对小鼠S180 实体瘤抑瘤率的差别。结果: 低剂量人参茎叶皂甙( 15 mg·kg^-1) 与氟脲嘧啶( 1. 5 mg·kg^-1) 组方对小鼠S180 实体瘤有显著的抑瘤作用( 抑瘤率达26. 90 %, P <0. 05), 对胸腺无抑制作用;阳性对照药5-FU( 25 mg·kg^-1) 的抑瘤率为36. 61 %, 但其对胸腺有显著抑制作用;而人参茎叶皂甙( 100 mg·kg^-1) 单用对小鼠S180 实体瘤抑瘤率为27. 44 %。结论: 低剂量人参茎叶皂甙( 15 mg·kg^-1) 显著促进5-FU( 1. 5mg·kg^-1) 对小鼠S180 实体瘤的抑瘤作用而无胸腺抑制作用, 可并减少5-FU 的毒副作用。

Enhancement of ginsen-stem-leaves to the antitumor effect of 5-FU in mice inoculated S180

AIM: To observe the enhancement of ginsen-stem-leaves (GSL) to the antitumor effect of 5-FU in mice inoculated S180. METHODS: The different combinations of GSL and 5-FU were used to examine the inhibition rates of tumor growth in KM mice inoculated S180. RESULTS: The combination of GSL ( 15 mg·kg^-1) and 5-FU ( 1. 5 mg·kg^-1) obtained 26. 90 % of inhibition rates of tumor growth ( P <0. 05), and did not inhibit the thymus. The antitumor rate of 5-FU ( 25 mg·kg^-1) was 36. 61 %, and the dose markedly decreased the weight of thymus. CONCLUSION: The combination of GSL ( 15 mg·kg^-1) and 5-FU ( 1. 5mg·kg^-1) can markedly inhibit the tumor growth of S180 inmice, but does not decrease the weight of thymus, suggesting that the combination may decrease the side effect produced by 5-FU.