| 魔芋葡甘聚糖对动脉粥样硬化家兔血清一氧化氮、血浆内皮素和脂质过氧化物的影响1 |
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| 引用本文： | 刘红.魔芋葡甘聚糖对动脉粥样硬化家兔血清一氧化氮、血浆内皮素和脂质过氧化物的影响1[J].金属学报,2002,7(6):534-535. |
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| 作者姓名： | 刘红 |
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| 作者单位： | 湖北民族学院医学院药理教研室,恩施 445000 |
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| 基金项目： | 1 湖北省教育厅重点资助项目(No2000A09010) |
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| 摘 要： | 目的 观察魔芋葡甘聚糖预防用药对动脉粥样硬化(AS)家兔血清一氧化氮(NO),血浆内皮素(ET)、脂质过氧化物(MDA)和超氧化物歧化酶(SOD)的影响。方法 采用高胆固醇饲料喂饲另加牛血清白蛋白一次注射方法,建立家兔AS 模型,随机分为对照组(n=8),模型组(n=8)和魔芋葡甘聚糖用药组(n=8),各组在实验第8 周取血清标本测定血清NO,血浆ET 、MDA 和SOD 。结果 与模型组比较,魔芋葡甘聚糖预防用药8 周,能提高NO 和SOD 活性(P <0.01),降低ET 和MDA 含量(P <0.01)。结论 魔芋葡甘聚糖具有抗氧化、保护内皮功能和维持NO/ET 平衡的作用。
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| 关 键 词： | 动脉粥样硬化 一氧化氮 内皮素 脂质过氧化物 魔芋葡甘聚糖 |
| 收稿时间： | 2002-06-11 |
| 修稿时间： | 2002-08-09 |
Effects of glucomanan on nitric oxide,endothelin and lipid peroxidation in atheroscierotic rabbits |
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| LIU Hong.Effects of glucomanan on nitric oxide,endothelin and lipid peroxidation in atheroscierotic rabbits[J].Acta Metallurgica Sinica,2002,7(6):534-535. |
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| Authors: | LIU Hong |
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| Affiliation: | Department of Pharmacology,Medical School of Hubei Institute for Nationalities,Enshi 445000 |
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| Abstract: | AIM: To observe the effects of glucomannan on nitric oxide(NO),endothelin(ET),lipid peroxide and superoxide dismutase(SOD)in experimental atherosclerotic rabbits.METHODS: An atherosclerotic rabbit model was established by feeding high cholesterol diet supplemented by bovine serum albumin injection bolus.The rabbits were randomly divided into the control,model,and glucomanan treatment group.Blood samples were collected 8 weeks after the treatment.RESULTS: After glucomanan administration for 8 wk,the NO and activity of SOD increased in comparison with model group(p<0.01),while MDA and ET decreased(p<0.01).CONCLUSION: Glucomanan has the effects of antioxidation,preserving endothelial function,and maintaining the balance of NO/ET. |
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| Keywords: | atherosclerosis nitric oxide endothelin lipid peroxide glucomanan |
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