小剂量氚水宫内辐射对出生后仔鼠行为、学习及记忆能力的影响

报道了在妊娠期以单次腹腔注入氚水,宫内受到累积剂量分别为0、0.05、0.10和0.30Gyβ射丝辐射后,对雄性仔鼠行为、学习及记忆能力的影响。研究发现0.10Gy以上剂量组对旷场行为,跳台学习及记忆能力、食物迷宫、水迷宫和孔板探究等多项测试指标均有影响,表现为早期兴奋性增强、晚期抑制及学习记忆能力的减退。结果提示阈剂量大约在0.05和0.10 Gy之间。

EFFECTS OF LOW LEVEL PRENATAL BETA-IRRADIATION OF TRITIATED WATER ON POSTNATAL BEHAVIOR,LEARNING AND MEMORY ABILITY IN MICE

Pregnant adult C 57 BL/6 J strain mice, randomly assigned to 1 of4 experimental groups, were irradiated with exponentially decreasing doses of tritiumbeta-rays but group 1 (used as a control) by single injection of tritiated water(HTO) at their 12.5 th day of gestation. Offsprings of male, received accumulativedoses of 0, 0.5, 0.10 or 0.30 Gy in uterus were trained or examined on learningand memory ability or with behavioral tests. Significant dose-response relationshipsfor alternations in those tests were found due to exposure to 0.10 Gy or above.These results indicate that exposure to HTO during the fetal period in mice resultsin dose-dependent alteration in postnatal behavior, learning and memory ability.0.05--0.10 Gy exposure may represent a threshold for the experimental conditionsof this research using these parameters.