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Design of a novel device for liver cancer biomarker detection
作者姓名:王帅鹏  王晶晶  朱银芳  杨晋玲  杨富华
基金项目:Project supported by the State Key Development Program for Basic Research of China;and the National Natural Science Foundation of China
摘    要:

修稿时间:5/4/2014 12:00:00 AM

Cantilever with immobilized antibody for liver cancer biomarker detection
Wang Shuaipeng,Wang Jingjing,Zhu Yinfang,Yang Jinling and Yang Fuhua.Design of a novel device for liver cancer biomarker detection[J].Chinese Journal of Semiconductors,2014,35(10):104008-6.
Authors:Wang Shuaipeng  Wang Jingjing  Zhu Yinfang  Yang Jinling and Yang Fuhua
Affiliation:Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China;State Key Laboratory of Transducer Technology, Shanghai 200050, China;Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China;State Key Laboratory of Transducer Technology, Shanghai 200050, China;Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China;State Key Laboratory of Transducer Technology, Shanghai 200050, China;Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China;State Key Laboratory of Transducer Technology, Shanghai 200050, China;Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China
Abstract:A novel cantilever array-based bio-sensor was batch-fabricated with IC compatible MEMS technology for precise liver cancer bio-marker detection. A micro-cavity was designed in the free end of the cantilever for local antibody-immobilization, thus the adsorption of the cancer biomarker takes place only in the local region of the cantilever instead of the whole lever, and the effect of adsorption-induced k variation can be dramatically reduced. These structural features offer several advantages: high sensitivity, high throughput, high mass detection accuracy, and a portable system. In addition, an analytical model has been established to eliminate the effect of the adsorption-induced lever stiffness change and has been applied to the precise mass detection of the cancer biomarker AFP; the experimentally detected AFP antigen mass by the sensor (7.6 pg/mL) is quite close to the calculated one (5.5 pg/mL), two orders of magnitude better than those of the fully antibody-immobilized cantilever sensor. These approaches can promote real applications of the cantilever sensors in cancer diagnosis.
Keywords:MEMS cantilever  mass detection  liver cancer biomarker  local reaction  adsorption-induced stiffness change
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