一种缺陷阶梯型光学生物传感器的设计

针对目前酶、蛋白质等重要生物分子在检测中的问题,该文设计了一种缺陷阶梯型光学生物传感器,用严格耦合波分析(RCWA)法计算此传感器反射光谱的反射率。由模拟结果可得,传感器反射光谱的特定波峰处,激光的入射角度与待测生物分子折射率有良好的线性关系,且在75.4°固定的激光入射角度下,传感器反射光谱中的反射率与待测生物分子的折射率也有良好的线性关系。基于此结论可知,不仅可由传感器反射光谱的反射率得到待测生物分子的折射率,也可由激光的入射角度来得到待测生物分子的折射率,进而获取待测生物分子的信息。

Design of a Defective Ladder type Optical Biosensor

Aiming at the problems existing in the enzymes, proteins and other biological molecules detection, a kind of defective ladder type optical biosensor has been designed in this paper. The reflection efficiency of reflectance spectroscopy of biological is calculated by using the rigorous coupled wave analysis (RCWA). The simulation result showed that there exists a good linear relationship between the refractive index of the biomolecules and the incident angle of laser at specific peak of reflection spectrum of the biosensor. And there has a good linear relationship between the reflection efficiency of reflection spectrum of the biosensor and the refractive index of the biomolecules at a fixed laser incident angle of 75.4°. The conclusion indicates that not only the reflection efficiency of reflection spectrum of the biosensor but also the incident angle of laser can detect the refractive index of the biomolecules, and then can get the information of biomolecules.