| 硼替佐米为主方案治疗难治/复发轻链型多发性骨髓瘤 |
| |
| 引用本文： | 吴亚妹,王志红,马健,曹永彬,徐丽昕,刘蓓,闫蓓,刘周阳,吴晓雄,高春记,达万明.硼替佐米为主方案治疗难治/复发轻链型多发性骨髓瘤[J].压电与声光,2010(1):19-21. |
| |
| 作者姓名： | 吴亚妹 王志红 马健 曹永彬 徐丽昕 刘蓓 闫蓓 刘周阳 吴晓雄 高春记 达万明 |
| |
| 作者单位： | [1]解放军总医院304临床部血液科,北京100048 [2]解放军总医院血液科,北京100853 |
| |
| 摘 要： | 目的了解硼替佐米对难治／复发性轻链型多发性骨髓瘤的疗效。方法采用BD／BP、BAD／BAP、BAEP及BVAD方案治疗14例轻链型MM患者。结果14例患者中，CR1例，nCR2例，PR5例，ORR8例。6例合并肾功能不全患者与8例肾功能正常患者的疗效相近。不良反应主要有乏力、胃肠道反应、末梢神经炎、血小板减少等，均可耐受。结论硼替佐米对部分已对化疗耐药的难治／复发性轻链型MM仍然有效，且效果显著。
|
| 关 键 词： | 多发性骨髓瘤 硼替佐米 治疗结果 |
Effects of bortezomib on refractory or relapsed light-chain multiple myeloma |
| |
| WU Ya-mei,WANG Zhi-hong,MA Jian,CAO Yong-bin,XU Li-xin,LIU Pei,YAN Pei,LIU Zhou-yang,WU Xiao-xiong,GAO Chun-ji,DA Wan-ming.Effects of bortezomib on refractory or relapsed light-chain multiple myeloma[J].Piezoelectrics & Acoustooptics,2010(1):19-21. |
| |
| Authors: | WU Ya-mei WANG Zhi-hong MA Jian CAO Yong-bin XU Li-xin LIU Pei YAN Pei LIU Zhou-yang WU Xiao-xiong GAO Chun-ji DA Wan-ming |
| |
| Affiliation: | WU Ya-mei1,WANG Zhi-hong1,MA Jian1,CAO Yong-bin1,XU Li-xin1,LIU Pei1,YAN Pei1,LIU Zhou-yang1,WU Xiao-xiong1,GAO Chun-ji2,DA Wan-ming21Department of Hematology,304 Clinical Division,Chinese PLA General Hospital,Beijing 100048,China,2Department of Hematology,Beijing 100853 |
| |
| Abstract: | Objective To elucidate the curative effects and toxicity of bortezomib on refractory or relapsed light-chain multiple myeloma (MM). Methods Fourteen patients with refractory or relapsed light-chain MM were treated with BD/BP, BAD/BAP, and BAEP or BVAD. Results The complete, near complete, and partial remission rate was 7.1%(1/14), 14.2%(2/14), and 35.7%(5/11), respectively, with an overall response rate of 57.1%. The response rate of patients with and without renal impairment was similar. The main toxicitie... |
| |
| Keywords: | Multiple Myeloma Bortezomib Treatment Outcome |
|
| 点击此处可从《压电与声光》浏览原始摘要信息 |
|
点击此处可从《压电与声光》下载全文 |
|
