| 具有质量和电化学复合敏感效应的新型QCM生物传感器研究 |
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| 引用本文： | 潘齐超,张瞳,张耀鹏,朱波.具有质量和电化学复合敏感效应的新型QCM生物传感器研究[J].压电与声光,2022,44(6):860-864. |
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| 作者姓名： | 潘齐超 张瞳 张耀鹏 朱波 |
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| 作者单位： | 东华大学 材料科学与工程学院,纤维材料改性国家重点实验室,上海 201620;上海大学 材料学院,上海 200444 |
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| 基金项目： | 国家自然科学基金资助项目(22175111) |
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| 摘 要： | 石英晶体微天平(QCM)是一种传统的质量敏感型传感器,具有灵敏度高及响应时间短等优点。为拓展QCM技术在液相生物分子传感领域的应用,该文通过电化学方法在QCM表面沉积生物分子功能化的导电高分子后,成功制备了链霉亲和素敏感的QCM传感器。该传感器不仅具有对链霉亲和素的质量和电化学复合敏感效应,而且具有优异的抗其他蛋白干扰能力,有进一步应用于液相生化传感和疾病检测的潜力。
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| 关 键 词： | 石英晶体微天平 生物分子检测 导电高分子 电化学传感 |
Study on a Novel QCM Biosensor with Integrated Mass andElectrochemical Sensitivity |
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| PAN Qichao,ZHANG Tong,ZHANG Yaopeng,ZHU Bo.Study on a Novel QCM Biosensor with Integrated Mass andElectrochemical Sensitivity[J].Piezoelectrics & Acoustooptics,2022,44(6):860-864. |
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| Authors: | PAN Qichao ZHANG Tong ZHANG Yaopeng ZHU Bo |
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| Affiliation: | State Key Lab.for Modification of Chemical Fibers and Polymer Materials, College of Materials Science andEngineering, Donghua University, Shanghai 201620 ,China;School of Materials Science and Engineering, Shanghai University, Shanghai 200444 ,China |
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| Abstract: | The quartz crystal microbalance(QCM) is a mass-sensitive sensor with the advantages of high sensitivity and short response time. In order to expand the application of QCM technology in the field of liquid phase biomolecular sensing, a streptavidin-sensitive QCM sensor was successfully fabricated by electrochemically depositing the biomolecule-functionalized conducting polymers on the surface of QCM. The sensor can not only simultaneously realize the mass and electrochemical sensing of the streptavidin, but also has excellent anti-inteference ability against othor proteins. It has the potential to be further applied to liquid phase biochemical sensing and disease detection. |
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