表面增强激光拉曼法（SERS）研究铝酞菁对不同核酸碱基的光敏损伤

将表面增强激光拉曼技术（ＳＥＲＳ）作为探针引入光敏损伤的研究。利用这种新的光谱方法研究了新光敏剂铝酞菁对几种核酸碱基分子的光敏损伤过程，发现Ｇ（乌嘌呤）对光敏化的敏感性最强，Ａ（腺嘌呤）其次，Ｃ（胞嘧啶）和Ｕ（尿嘧啶）则不敏感。实验证实，是铝酞菁的光动力反应产物单线态氧，在核酸碱基的光敏损伤中起主要作用。

Study on the Photosensitization of the Nucleic Acid Bases Senitized by ALPCS with the Method of SERS

In this paper,the SERS(Surface enhanced Raman scattering) method is for the first time employed as a probe to investigate the interaction between the photosensitizer ALPCS and the nucleic acid bases.The advantage of this method is that it can Provide important information on the sensitive slids and damaging process which can't be achieved by other methods.The obtained results suggest that G(Guanine) is most senSitive and vulnerable and the A(Adenine) is less vulnerable,while C(Cytedne) and U(Uracil) are totally not sensitive to the photosensitizer at all.The experiments have confirmed that singlet oxygen, the product of ALPCS photodynaxnic reaction,pays an importmant role in the damaging process of G and A.