β-内酰胺类抗生素药物的太赫兹光

-内酰胺类是临床上应用最广泛的抗生素，具有广谱、高效和安全的特点。抗生素的鉴别和质量检查非常重要。相比其他光谱手段，太赫兹光谱具有许多独特的优势。利用太赫兹时域光谱（THz-TDS）技术在常温下研究了6种临床常用抗生素类药物，获得了它们的太赫兹吸收光谱。测试结果表明:即使分子结构相似，但它们的太赫兹光谱具有明显不同的特征，说明THz-TDS技术能够鉴别这种分子结构的微小差异，可以很好地用于药品检测和分析，在药品的研制、生产和鉴别方面具有很好的应用前景。最后利用Gaussian 03软件计算了青霉素钠分子在0.2~2.5 THz的振动吸收光谱，与实验结果进行比较，并对其振动模式进行指认。

Terahertz spectroscopy of β-lactam antibiotics

-lactam antibiotics are widely used in clinical practice, for their broad-spectrum, high efficiency and safety features. The identification and quality inspection of antibiotics are very important. Compared to other spectral methods, terahertz spectroscopy has some special advantages. In this paper, six kinds of antibiotics of clinical medication were tested using terahertz time domain spectroscopy(THz-TDS), and their terahertz absorption spectra were got. The results show that the samples have obviously different terahertz spectral characteristics even though they have similar molecular structures, which proves that the THz-TDS technology can identify small differences in molecular structure. So it can be very useful in medicament testing and analysis, which guarantees a good prospect in medicament development, production and identification. Finally, the absorption spectrum of benzylpenicillin sodium from 0.2-2.5 THz was simulated by Gaussian 03 software. Compared with the measurement results, the vibrational modes of the sample were assigned.