| 米诺环素对大鼠慢性高眼压视网膜神经保护作用探讨 |
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| 引用本文： | 熊海波. 米诺环素对大鼠慢性高眼压视网膜神经保护作用探讨[J]. 激光杂志, 2011, 0(4): 90-91 |
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| 作者姓名： | 熊海波 |
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| 作者单位： | 重庆市第三人民医院眼科,重庆400014 |
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| 摘 要： | 目的：探讨米诺环素对大鼠慢性高眼压视网膜神经保护作用。方法：88只SD大鼠分为正常对照组8只,高眼压组和治疗组各40只。烧灼表浅巩膜静脉建立大鼠慢性高眼压模型,于1、7、14、28d检测视网膜电图（electroretinogram,ERG）b波振幅,分光光度计测定超氧化物歧化酶（SOD）,丙二醛（MOA）,一氧化氮（...
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| 关 键 词： | 慢性高眼压 青光眼 视网膜神经节细胞 米诺环素 |
Neuroprotection of minocycline on chronic ocular hypertension rat retina |
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| XIONG Hai-bo. Neuroprotection of minocycline on chronic ocular hypertension rat retina[J]. Laser Journal, 2011, 0(4): 90-91 |
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| Authors: | XIONG Hai-bo |
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| Affiliation: | XIONG Hai-bo(Department of Ophthalmology,Third People＇s Hospital of Chongqing,Chongqing 400014,China) |
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| Abstract: | Purpose：To observe retinal neuro protection of minocycline on chronic ocular hypertension rat.Methods：88 SD rats were divided into normal control group,high intraocular pressure group and treatment group.To cauterize superficial scleral vein ablation in order to establish chronic ocular hypertension rat model.We tested ERG b wave amplitude,superoxide dismutase（SOD）,malondialdehyde（MDA） and nitric oxide （NO） by spectrophotometer.Results：Compared with high intraocular pressure group,the treatment group ERG b wave amplitude can be maintained,SOD content were increased,MDA and NO content were decreased.Conclusion：Minocycline can protect retina by maintaining ERG b wave amplitude and controling SOD,MDA and NO content. |
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| Keywords: | chronic ocular hypertension glaucoma retinal ganglion cells minocycline |
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