| shRNA靶向干扰COX-2促进人肝癌裸鼠皮下移植瘤肿瘤细胞凋亡 |
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| 引用本文： | 陈光辉,涂植光,孔飞飞,邱欣欣,成风,匡文斌,李朴,刘预.shRNA靶向干扰COX-2促进人肝癌裸鼠皮下移植瘤肿瘤细胞凋亡[J].四川激光,2011(4):64-66. |
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| 作者姓名： | 陈光辉 涂植光 孔飞飞 邱欣欣 成风 匡文斌 李朴 刘预 |
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| 作者单位： | [1]重庆市肿瘤研究所临床检验中心,重庆400030 [2]重庆医科大学医学检验系临床检验诊断学教育部重点实验室,重庆400016 |
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| 基金项目： | 重庆市科委自然科学基金项目（项目编号：2006BB5271） |
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| 摘 要： | 目的：探讨重组干扰质粒pshRNA-COX-2对人肝癌细胞Hep3B裸鼠皮下移植瘤肿瘤细胞凋亡的促进作用。方法：重组干扰质粒pshRNA-COX-2转染Hep3B细胞并筛选后,将被成功转染的Hep3B细胞种植于裸鼠皮下,测量肿瘤大小,成瘤4周后处死裸鼠,绘制肿瘤生长曲线,RT-PCR和Western blot检测肿瘤组...
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| 关 键 词： | 肝癌 环氧化酶-2 重组干扰质粒pshRNA-COX-2 皮下移植瘤 凋亡 |
Promotive effect of cyclooxygenase-2 gene inhibited by shRNA on the tumor cells apoptosis of subcutaneous xenograft human liver cancers in nude mice |
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| CHEN Guang-hui,TU Zhi-guang,KONG Fei-fei,QIU Xin-xin,CHENG Feng,KUANG Wen-bin,LI Pu,LIU Yu.Promotive effect of cyclooxygenase-2 gene inhibited by shRNA on the tumor cells apoptosis of subcutaneous xenograft human liver cancers in nude mice[J].Laser Journal,2011(4):64-66. |
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| Authors: | CHEN Guang-hui TU Zhi-guang KONG Fei-fei QIU Xin-xin CHENG Feng KUANG Wen-bin LI Pu LIU Yu |
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| Affiliation: | 1.Clinical Laboratory Center,Chongqing Cancer Institute,Chongqing 400030,China;2.Key Laboratory of Laboratory Medical Diagnostics of Ministry of Education,Faculty of Laboratory Medicine,Chongqing Medical University,Chongqing 400016,China |
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| Abstract: | |
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| Keywords: | human liver cancer cyclooxygenase-2 recombinant interference plasmid pshRNA-COX-2 subcutaneous xenograft tumor apoptosis |
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