| 小鼠在体皮下乳腺癌的太赫兹波成像检测研究 |
| |
| 引用本文： | 武丽敏,廖彬,徐德刚,王与烨,葛梅兰,张超楠,李佳桦,孙忠成,陈图南,冯华,姚建铨.小鼠在体皮下乳腺癌的太赫兹波成像检测研究[J].红外与毫米波学报,2020,39(5):553-560. |
| |
| 作者姓名： | 武丽敏 廖彬 徐德刚 王与烨 葛梅兰 张超楠 李佳桦 孙忠成 陈图南 冯华 姚建铨 |
| |
| 作者单位： | 天津大学精密仪器与光电子工程学院激光与光电子研究所,天津300072;天津大学光电信息技术教育部重点实验室,天津300072;陆军军医大学第一附属医院神经外科,重庆400038;天津大学精密仪器与光电子工程学院激光与光电子研究所,天津300072;天津大学光电信息技术教育部重点实验室,天津300072;陆军军医大学第一附属医院神经外科,重庆400038;天津大学生命科学学院天津市微纳生物材料与检疗工程技术中心,天津300072 |
| |
| 基金项目： | 国家 973 计划 2015CB755403;国家自然科学基金 61775160 61771332;中国博士后科学基金特别资助 2016M602954;重庆市博士后科研项目特别资助 Xm2016021;重庆西南医院生物强院科技创新计划 SWH2016LHJC04 SWH2016LHJC01国家 973 计划（2015CB755403）、国家自然科学基金（61775160, 61771332）、中国博士后科学基金特别资助（2016M602954）、重庆市博士后科研项目特别资助（Xm2016021）、重庆西南医院生物强院科技创新计划（SWH2016LHJC04, SWH2016LHJC01） |
| |
| 摘 要： | 乳腺癌是女性常见癌症之一，乳腺癌区域的精准检测对乳腺癌的治疗有至关重要的作用。本文采用频率为2.52THz的连续太赫兹波反射式成像系统，对小鼠在体皮下乳腺癌模型进行了太赫兹波成像检测。研究结果表明，太赫兹波成像可以清晰识别出乳腺癌区域，且与肉眼可见肿瘤区域一致。在体乳腺癌区域的太赫兹波相对反射率高于正常组织，两者相对反射率差值高达15%。进一步，对距离皮肤表面不同深度的离体乳腺癌组织进行切片和苏木精-伊红(H&E)染色，作为金标准对照。结果发现乳腺癌区域的面积随着距离皮肤表面深度的增加而增大。通过将太赫兹波成像与H&E染色结果对比可知，在距离皮肤表面约460μm处，太赫兹波图像和H&E染色图中的肿瘤区域面积相等。由此可知，太赫兹波对在体皮下乳腺癌的探测深度大约在460μm左右，太赫兹波有望实现深部肿瘤的检测。
|
| 关 键 词： | 乳腺癌 连续太赫兹波 反射成像 乳腺肿瘤诊断 |
| 收稿时间： | 2019/9/26 0:00:00 |
| 修稿时间： | 2020/8/16 0:00:00 |
Study of in-vivo breast cancer in a subcutaneous xenograft mouse model using terahertz imaging |
| |
| Wu Limin,Liao Bin,Xu Degang,Wang Yuye,Ge Meilan,Zhang Chaonan,Li Jiahu,Sun Zhongcehng,Chen Tunan,Feng Hua and Yao Jianquan.Study of in-vivo breast cancer in a subcutaneous xenograft mouse model using terahertz imaging[J].Journal of Infrared and Millimeter Waves,2020,39(5):553-560. |
| |
| Authors: | Wu Limin Liao Bin Xu Degang Wang Yuye Ge Meilan Zhang Chaonan Li Jiahu Sun Zhongcehng Chen Tunan Feng Hua and Yao Jianquan |
| |
| Affiliation: | Institute of Laser and Optoelectronics, School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China;Key Laboratory of Optoelectronics Information Technology (Ministry of Education), Tianjin University, Tianjin 300072, China,Institute of Neurosurgery, Southwest Hospital, Army Medical University, Chongqing;400038, China,Institute of Laser and Optoelectronics, School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China;Key Laboratory of Optoelectronics Information Technology (Ministry of Education), Tianjin University, Tianjin 300072, China,Institute of Laser and Optoelectronics, School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China;Key Laboratory of Optoelectronics Information Technology (Ministry of Education), Tianjin University, Tianjin 300072, China;Institute of Neurosurgery, Southwest Hospital, Army Medical University, Chongqing;400038, China,Institute of Laser and Optoelectronics, School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China;Key Laboratory of Optoelectronics Information Technology (Ministry of Education), Tianjin University, Tianjin 300072, China,School of Life Sciences, Tianjin Engineering Center of Micro-Nano Biomaterials, Tianjin University, Tianjin 300072, China,School of Life Sciences, Tianjin Engineering Center of Micro-Nano Biomaterials, Tianjin University, Tianjin 300072, China,Institute of Laser and Optoelectronics, School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China;Key Laboratory of Optoelectronics Information Technology (Ministry of Education), Tianjin University, Tianjin 300072, China,Institute of Neurosurgery, Southwest Hospital, Army Medical University, Chongqing;400038, China,Institute of Neurosurgery, Southwest Hospital, Army Medical University, Chongqing;400038, China,Institute of Laser and Optoelectronics, School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China;Key Laboratory of Optoelectronics Information Technology (Ministry of Education), Tianjin University, Tianjin 300072, China |
| |
| Abstract: | Breast cancer (BC) is one of the most common diseases in women. The accurate detection for BC is very important in clinical practice. In this paper, in-vivo breast cancer in a subcutaneous xenograft mouse was studied with the continuous-wave terahertz (THz) reflection imaging system at 2.52THz. The high reflection region in THz images of in-vivo subcutaneous xenograft mouse corresponded well to the tumor area in visible. The difference value of 15% between tumor and normal tissues was observed. For the gold standard, the tumor areas at different depths from the surface of skin in mouse model were obtained by hematoxylin and |
| |
| Keywords: | Breast cancer continuous terahertz wave reflection imaging |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《红外与毫米波学报》浏览原始摘要信息 |
|
点击此处可从《红外与毫米波学报》下载全文 |
|
