周围神经修复过程的超微结构研究

为了解周围神经损伤后的修复过程，观察了大鼠坐骨神经冷冻损伤当时至４周后的超微结构。发现冷冻损伤后３天，除变性神经纤维外，有新生轴突，皆由雪旺细胞包裹着。１周皇一神经纤维已较丰富，以无髓纤维为多，遥髓纤维罕见，且髓鞘较薄，雪量细胞和巨噬细胞皆吞噬变性的神经纤维。此后，形态正常的雪旺细胞和神经纤维渐多，被吴噬的变性物质渐少，直至损伤４周后，神经组织恢复到基本正常，但仍可见少量被吞噬的髓样结构。这提示，

Untrastructural study of repairing process on peripheral nerve

To finding out the repairing process of injured peripheral nerve,we observed the changes of ultrastructure of crymo-injured sciatic nerve from beginning to 4th week in rats.The results showed that some newborn axon encysted with Schwann's cell was found besides degenerated nerve fibers in 3 days of crymo-injury.A wee k later,newborn nerve fibers were riched in which unmyelinated fibers were much more than the myelinated fibers,Schwann's cell and microphagocyte phagocytosed t he degenerated nerve fibers.After that,normal Schwann's cell and nerve fibers in c reased gradually and the degenerated substances decreased.Up to 4th week,there s till were little phagocytosed medullary structure.Out observation revealed that sciatic nerve damaged by refrigeration began regeneration after 3days.A week lat er,medullary nerve fibers appeared and the repaired process basically finished u ntil 4th week.