左旋氨氯地平对急性心肌梗死犬心肌细胞的超微结构影响

目的：观察左旋氨氯地平(L-Amlodipine)对急性心肌梗死犬心肌酶和心肌细胞超微结构的影响。方法：采用麻醉开胸结扎犬的冠状动脉左前降支制备急性心肌梗死模型，取静脉血检测心肌天门冬氨酸转氨酶(AST)、磷酸肌酸激酶(CPK)和乳酸脱氢酶(LDH)活性；用透射电镜观察心肌细胞超微结构的改变。结果：左旋氨氯地平可以降低心肌酶的活性，减轻缺血造成的心肌细胞损伤程度。结论：左旋氨氯地平对缺血性心肌细胞损伤具有一定的保护作用。

Effect of L-Amlodipine on ultrastructure of myocardium in dogs with experimental myocardial infarct

This paper investigated the effects of L-Amlodipine on myocardial enzymes and ultrastructure of myocardium in dogs with experimental myocardial infarction. We divided 25 dogs into five groups: (1) control group (2) Amlodipine control group (3) high-dose L-Amlodipine group (4) middle-dose L-Amlodipine group (5) low-dose L-Amlodipine group. An acute myocardial infarction model was made by ligating left anterior descending branch in anesthetic dog. We detected content of myocardial enzymes (AST, CPK, LDH) in blood serum and observed changes of myocardial ultrastructure.The results showed that L-Amlodipine can reduce the ultrastructural injuries of myocardium and diminish the myocardial enzyme activity of blood serum. So we can draw a conclusion that L-Amlodipine might protect cardiac muscle against ischemic myocardial injury.