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Customizing MRI-Compatible Multifunctional Neural Interfaces through Fiber Drawing |
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| Authors: | Marc-Joseph Antonini Atharva Sahasrabudhe Anthony Tabet Miriam Schwalm Dekel Rosenfeld Indie Garwood Jimin Park Gabriel Loke Tural Khudiyev Mehmet Kanik Nathan Corbin Andres Canales Alan Jasanoff Yoel Fink Polina Anikeeva |
| Affiliation: | 1. Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA;2. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA;3. Harvard/MIT Health Sciences and Technology Graduate Program, Cambridge, MA, 02139 USA;4. Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA
Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA;5. Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA Kinetik Therapeutics LLC, Newton, MA, 02459 USA;6. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA;7. Advanced Silicon Group, Lowell, MA, 01854 USA;8. McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA;9. Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA Advanced Functional Fabrics of America, Cambridge, MA, 02139 USA Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA |
| Abstract: | Fiber drawing enables scalable fabrication of multifunctional flexible fibers that integrate electrical, optical, and microfluidic modalities to record and modulate neural activity. Constraints on thermomechanical properties of materials, however, have prevented integrated drawing of metal electrodes with low-loss polymer waveguides for concurrent electrical recording and optical neuromodulation. Here, two fabrication approaches are introduced: 1) an iterative thermal drawing with a soft, low melting temperature (Tm) metal indium, and 2) a metal convergence drawing with traditionally non-drawable high Tm metal tungsten. Both approaches deliver multifunctional flexible neural interfaces with low-impedance metallic electrodes and low-loss waveguides, capable of recording optically-evoked and spontaneous neural activity in mice over several weeks. These fibers are coupled with a light-weight mechanical microdrive (1 g) that enables depth-specific interrogation of neural circuits in mice following chronic implantation. Finally, the compatibility of these fibers with magnetic resonance imaging is demonstrated and they are applied to visualize the delivery of chemical payloads through the integrated channels in real time. Together, these advances expand the domains of application of the fiber-based neural probes in neuroscience and neuroengineering. |
| Keywords: | fibers magnetic resonance imaging microdrives multifunctional neural probes thermal drawing |