首页 | 本学科首页   官方微博 | 高级检索  
     


Engineering Bioactive M2 Macrophage-Polarized Anti-Inflammatory,Antioxidant, and Antibacterial Scaffolds for Rapid Angiogenesis and Diabetic Wound Repair
Authors:Zhuolong Tu  Mi Chen  Min Wang  Zhenxuan Shao  Xiaoqi Jiang  Kangyan Wang  Zhe Yao  Shiwei Yang  Xingxing Zhang  Weiyang Gao  Cai Lin  Bo Lei  Cong Mao
Affiliation:1. Key Laboratory of Orthopedics of Zhejiang Province, Department of Orthopedics, , the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027 China

Department of Burn, , the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000 China;2. Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710000 China;3. Key Laboratory of Orthopedics of Zhejiang Province, Department of Orthopedics, , the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027 China;4. Department of Burn, , the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000 China

Abstract:Diabetic wound healing still faces great challenges due to the excessive inflammation, easy infection, and impaired angiogenesis in wound beds. The immunoregulation of macrophages polarization toward M2 phenotype that facilitates the transition from inflammation to proliferation phase has been proved to be an effective way to improve diabetic wound healing. Herein, an M2 phenotype-enabled anti-inflammatory, antioxidant, and antibacterial conductive hydrogel scaffolds (GDFE) for producing rapid angiogenesis and diabetic wound repair are reported. The GDFE scaffolds are fabricated facilely through the dynamic crosslinking between polypeptide and polydopamine and graphene oxide. The GDFE scaffolds possess thermosensitivity, self-healing behavior, injectability, broad-spectrum antibacterial activity, antioxidant and anti-inflammatory ability, and electronic conductivity. GDFE effectively activates the polarization of macrophages toward M2 phenotype and significantly promotes the proliferation of dermal fibroblasts, the migration, and in vitro angiogenesis of endothelial cells through paracrine mechanisms. The in vivo results from a full-thickness diabetic wound model demonstrate that GDFE can rapidly promote the diabetic wound repair and skin regeneration, through fast anti-inflammation and angiogenesis and M2 macrophage polarization. This study provides highly efficient strategy for treating diabetic wound repair through designing the M2 polarization-enabled anti-inflammatory, antioxidant, and antibacterial bioactive materials.
Keywords:angiogenesis  anti-inflammation activity  diabetic wound repair  macrophages polarization  multifunctional bioactive scaffolds
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号