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Engineered Bicomponent Adhesives with Instantaneous and Superior Adhesion Performance for Wound Sealing and Healing Applications |
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| Authors: | Kelu Zhao Bo Li Yao Sun Bo Jia Jing Chen Wenhao Cheng Lai Zhao Jingjing Li Fan Wang Juanjuan Su Jing Sun Bing Han Yawei Liu Hongjie Zhang Kai Liu |
| Affiliation: | 1. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
University of Science and Technology of China, Hefei, 230026 China;2. Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084 China;3. Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084 China Xiangfu Laboratory, Jiaxing, Zhejiang, 314102 China;4. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China;5. College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing, 100049 China;6. School of Chemistry and Molecular Engineering, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai, 200062 China;7. Department of Orthodontics, Cranial-Facial Growth, and Development Center, Peking University School and Hospital of Stomatology and National Center of Stomatology and National Clinical Research Center for Oral Diseases and National Engineering Laboratory for Digital and Material Technology of Stomatology, 22 Zhongguancun South Avenue, Haidian District, Beijing, 100081 China;8. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China University of Science and Technology of China, Hefei, 230026 China Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084 China Xiangfu Laboratory, Jiaxing, Zhejiang, 314102 China |
| Abstract: | Surgical adhesives are playing an important role in wound repair and emergency hemostasis in clinical treatment. However, the development of strong bioglue with rapid in situ adhesion, durable adhesiveness, and flexibility in dynamic and moist physiological environments is still challenging. Herein, a new type of biosynthetic protein bioadhesives with superior adhesion performance is reported by developing a protein aldimine condensation strategy. Lysine-rich recombinant proteins are designed and massively biosynthesized to instantaneously react with aldehyde cross-linkers to realize in situ strong adhesion. The obtained bioadhesives show an ultra-high adhesion strength of ≈101.6 kPa on porcine skin, outperforming extant clinical bioglues. In addition, they possess super biocompatibility, flexibility, biodegradability, and compliance with the tissues. Owing to the strong and instantaneous adhesion properties, the bioadhesives are qualified for dynamic wound closure, facilitating wound repair, and noncompressible hemorrhage. Importantly, they can be industrially encapsulated into custom-made cartridge delivery tubes at low cost for clinical use. Therefore, biosynthetic bioadhesives have great potential for biological applications and are capable of scaling up to the industrial level for clinical transformation, which will be a successful paradigm for reforming existing clinical products. |
| Keywords: | bioglues cross-linkings interfacial adhesions protein engineering sealing and healing |