浮选剂找药分子设计理论的应用与发展

研制新型高效浮选剂是发展浮选技术的关键。国内外许多学者曾研究浮选药剂理论,并企图用于讨论机理及指导找药研究。本文简要评述了这些工作,通过例示介绍了浮选剂找药分子设计理论近年来在新药剂开发工作中取得的成效,系统地介绍了作者关于浮选剂找药分子设计理论及应用的研究成果。

RECENT DEVELOPMENT AND APPLICATION OF THEORY OF DESIGN OF MOLECULAR STRUCTURE OF FLOTATION AGENTS

In this article, some of the developments associated with the structure theory of flotation agent and its application are briefly reviewed. The author's work on the theory of designing molecular structure of flotation agent and its application are summarized. The main points of the theory include. (a) to establish a assembly model for various groups of the agents; (b) to classify the structure parameters affecting the properties of diverse groups into bonding factor, hydrophilic-hydrophobie balance factor and steric effect; (c) to determine the quantitative criterions for these structure parameters,such as MO parameter, group electronegatvity Xg, Character istie parameter of flotation agent and the diagram of group diameter (dg) Vs Xg; (d) to design molecular structure of flotation agent and predict its nature using these quantitative criterions.