| PLGA材料仿生改性的最新进展 |
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| 引用本文： | 陈剑,樊新,周忠诚,阮建明.PLGA材料仿生改性的最新进展[J].粉末冶金材料科学与工程,2008,13(6). |
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| 作者姓名： | 陈剑 樊新 周忠诚 阮建明 |
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| 作者单位： | 中南大学,粉末冶金国家重点实验室,长沙,410083 |
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| 基金项目： | 国家自然科学基金
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| 摘 要： | 聚乳酸-乙交酯（PLGA）因具有优良的可降解性而在医用生物材料中得到了广泛应用，然而由于其表面缺乏细胞识别位点，以及存在亲水性和细胞亲和性不足等缺点，影响了细胞在其表面的粘附生长。为了得到生物功能和亲水性均较理想的聚乳酸类生物降解高分子，通过物理或者化学的方法在材料中引入胶原或多肽对其进行改性，赋予材料生物信号，以提高其生物功能，使其在组织工程支架的研究和临床应用更加广泛。该文主要对PLGA仿生改性的最新进展进行综述。
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| 关 键 词： | 聚丙交酯-乙交酯（PLGA） 降解聚合物 亲水性 仿生改性 |
Latest advancement of poly lactic acid-glycolic acid (PLGA) materials bionic modification |
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| CHEN Jian,FAN Xin,ZHOU Zhong-cheng,RUAN Jian-ming.Latest advancement of poly lactic acid-glycolic acid (PLGA) materials bionic modification[J].materials science and engineering of powder metallurgy,2008,13(6). |
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| Authors: | CHEN Jian FAN Xin ZHOU Zhong-cheng RUAN Jian-ming |
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| Affiliation: | CHEN Jian,FAN Xin,ZHOU Zhong-cheng,RUAN Jian-ming (State Key Laboratory of Powder Metallurgy,Central South University,Changsha 410083,China) |
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| Abstract: | Poly(lactic co-glycolic acid) (PLGA) has the ability of degrdation which leads this kind of material applied widely to medical biomaterials. However, because the PLGA material lacks of surface cell discrimination points and has poor ability of hydrophilia and cellular affinity, surface cell adherent growing is poor. Therefore modification is needed in order to obtain ideal materials with fine bio-function and good hydrophilia, wherein physical and chemical method are used by introducing collagen and polypep... |
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| Keywords: | (LLA-GA)PLGA biodegradable polymer hydrophilia bionic modification |
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