| Bioeffects of Rare Earth Complex on Rats Studied by NMR and ICP-MS Spectroscopy |
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| 作者姓名： | 吴惠丰 李晓晶 廖沛球 吴亦洁 裴奉奎 聂毓秀 |
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| 作者单位： | Changchun Institute of Applied Chemistry，Chinese Academy of Sciences，Changchun 130022，China，Changchun Institute of Applied Chemistry，Chinese Academy of Sciences，Changchun 130022，China，Changchun Institute of Applied Chemistry，Chinese Academy of Sciences，Changchun 130022，China，Changchun Institute of Applied Chemistry，Chinese Academy of Sciences，Changchun 130022，China，Changchun Institute of Applied Chemistry，Chinese Academy of Sciences，Changchun 130022，China，College of Basic Medicine Science，Jilin University，Changchun 130021，China |
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| 基金项目： | ProjectsupportedbytheNationalNaturalScienceFoundationofChina(29890280) |
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| 摘 要： | Thedevelopmentofhigh fieldNMRspectrome terswithincreasedsensitivity,resolution,dynamic rangeandimprovedcomputingcapabilitieshasmade itpossibletouseNMRtechniqueforrapidmulticom ponentanalysisoflowMWcompoundsinbiofluids inordertoassessthetoxicologicaleffe…
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| 关 键 词： | 生物流体力学 NMR 稀土元素复合物 变清蛋白 诱导耦合等离子体-质量分光镜 |
Bioeffects of Rare Earth Complex on Rats Studied by NMR and ICP-MS Spectroscopy |
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| Wu Huifeng,LI Xiaojing,Liao Peiqiu,Wu Yijie,Pei Fengkui,Nie Yuxiu.Bioeffects of Rare Earth Complex on Rats Studied by NMR and ICP-MS Spectroscopy[J].Journal of Rare Earths,2005,23(2):245-250. |
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| Authors: | Wu Huifeng LI Xiaojing Liao Peiqiu Wu Yijie Pei Fengkui Nie Yuxiu |
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| Abstract: | The bioeffects of Changle, a rare earth complex on rats were investigated using NMR and ICP techniques. Wistar rats were administrated orally with Changle (a rare earth-containing fertilizer additive applied in agriculture to raise the production of crops) at doses of 2, 5 and 20 mg·kg-1 body weight/day respectively for 90 d. The urine of Changle-treated rats was collected at 45 and 90 d and serum samples were taken after 90 d. The relative concentrations of some important endogenous metabolites in biofluids were determined by 1H NMR spectra and the contents of the four rare earth elements (La, Ce, Pr and Nd) constituting Changle in the serum samples were measured by ICP-MS technique. Changle-induced renal and liver damage is demonstrated based on the increase in the amounts of the amino acids, trimethylamine N-oxide, N, N-dimethylglycine, dimethylamine, succinate, α-Ketoglutarate ethanol and the alteration of rare earth concentrations in serum. |
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| Keywords: | biofluids Changle NMR ICP-MS metabolism rare earths |
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