|
|||||
|
|
| 负载铜催化剂催化分子内Ullmann反应合成吲哚啉衍生物 | |
| 引用本文： | 杨荣强,聂振中,游梦云,张胜建.负载铜催化剂催化分子内Ullmann反应合成吲哚啉衍生物[J].广东化工,2012,39(1):37-38. |
| 作者姓名： | 杨荣强 聂振中 游梦云 张胜建 |
| 作者单位： | 1. 浙江台州清泉医药化工有限公司,浙江台州,317300 2. 江苏清泉化学有限公司,江苏盐城,224555 3. 浙江大学宁波理工学院,浙江宁波,315100 |
| 摘 要： | 制备TiO2、Al2O3、ZnO负载铜催化剂及改性负载铜催化剂,其中TiO2负载铜催化剂的收率最高。以邻氯苯乙胺、2-氯-β-甲基苯乙胺、2-氯-5-乙基苯乙胺、邻溴苯乙胺、4-甲氧基-2-氯苯乙胺、5-乙基-2-氯苯乙胺为原料,铜负载量15%的Cu/TiO2为催化剂,NaOH为缚酸剂,乙醇为溶剂,90℃反应8 h,可分别得到收率近94%的相应的吲哚啉衍生物。催化剂经过滤、二氯甲烷洗涤、焙烧,可重复使用。 |
| 关 键 词： | 负载铜催化剂 吲哚啉 Ullmann反应 邻氯苯乙胺法 |
The Synthesis of Indoline Derivatives by Intramolecular Ullmann Reaction Catalyzed by Supported Cu Catalysts |
|
| Yang Rongqiang,Nie Zhenzhong,You Mengyun,Zhang Shengjian.The Synthesis of Indoline Derivatives by Intramolecular Ullmann Reaction Catalyzed by Supported Cu Catalysts[J].Guangdong Chemical Industry,2012,39(1):37-38. | |
| Authors: | Yang Rongqiang Nie Zhenzhong You Mengyun Zhang Shengjian |
| Affiliation: | 1.Zhejiang Qingquan Chemical Co.,Ltd.,Taizhou 317300;2.Jiangsu Qingquan Chemical Co.,Ltd.,Yancheng 224555; 3.Ningbo Institute of Technology,Zhejiang University,Ningbo 315100,China) |
| Abstract: | Supported Cu catalysts of TiO2,Al2O3,ZnO and modified Supported Cu Catalyst were prepared.Using 2-chlorophenethyl-amine,2-chloro-β-methylphenethylamine,2-chloro-5-ethylphenethylamine,2-bromophenethylamine,4-methoxyl-2-chlorophenethylamine,5-ethyl-2-chloro-phenethylamine as substrates,15 % Cu/TiO2 as catalyst,NaOH as acid-trapping agent,ethanol as solvent,reaction in 90 ℃ for 8 h,could give relative indoline derivateives in 94 %~96 % yields.The catalyst could be reused after simple treatments as filter,washed by CH2Cl2 and roasted. |
| Keywords: | supported Cu Catalyst indoline ullmann reaction 2-chlorophenethylamine |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |