| 选择性乙酰辅酶A羧化酶2抑制剂（ACC2）苯氧基噻唑炔衍生物的合成改进 |
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| 引用本文： | 朱自力.选择性乙酰辅酶A羧化酶2抑制剂（ACC2）苯氧基噻唑炔衍生物的合成改进[J].广东化工,2009,36(4):23-24. |
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| 作者姓名： | 朱自力 |
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| 作者单位： | 华南理工大学,化学与化工学院,广东,广州,510640 |
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| 摘 要： | 文章采用廉价易得的原料对苯二酚，采取单烷氧基化，Sonogashira偶连，羟基保护，酰胺化等常见的化学反应，反应条件温和，收率较高，顺利合成了苯氧基噻唑炔类新化合物。化合物通过核磁共振波谱，质谱的确认。
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| 关 键 词： | Sonogashira偶连反应 Mitsunobu反应 酰胺化 |
Optimized Synthesis of Selective ACC2 Phenoxy Thiazole Acetylene Derivatives |
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| Zhu Zili.Optimized Synthesis of Selective ACC2 Phenoxy Thiazole Acetylene Derivatives[J].Guangdong Chemical Industry,2009,36(4):23-24. |
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| Authors: | Zhu Zili |
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| Affiliation: | Zhu Zili (School of Chemistry and Chemical Enjineering, South China University of Techinology, Guangzhou 510640, China) |
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| Abstract: | The paper used hydroquinone as the raw material, which was cheap and easy to get, took the common chemical reactions such as alkoxy, Sonogashira coupled, hydroxyl protection, amidation, the reaction conditions was mild and yield was high, synthesis the new phenoxy thiazole-based acetylene compounds smoothly. It was confirmed by 1HNMR and MS. |
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| Keywords: | sonogashira coupling reaction mitsunobu reaction amidation |
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