| O-邻氟苯甲基羟胺盐酸盐的合成 |
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| 引用本文： | 王伟,林勇,俞阳晨,张胜建,张洪.O-邻氟苯甲基羟胺盐酸盐的合成[J].广东化工,2012(4):65-66. |
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| 作者姓名： | 王伟 林勇 俞阳晨 张胜建 张洪 |
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| 作者单位： | [1]宁波工业投资集团有限公司,浙江宁波315000 [2]宁波欧迅化学新材料技术有限公司,浙江宁波315203 [3]浙江大学宁波理工学院,浙江宁波315100 |
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| 摘 要： | 以丙酮肟和邻氟氯苄为原料合成了O-2-氟苯甲基丙酮肟醚,再用盐酸水解得到了O-2-氟苯甲基羟胺盐酸盐。文章系统研究了反应温度、不同溶剂、溶剂含水量等各种实验因素对O-2-氟苯甲基丙酮肟醚的影响,研究了盐酸浓度、水解温度等因素对O-2-氟苯甲基丙酮肟醚水解工艺的影响。两步收率最高分别为92.3%和87.3%。并用核磁等对产品及中间体进行了表征。
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| 关 键 词： | O-2-氟苯甲基羟胺盐酸盐 丙酮肟 邻氟氯苄 DMSO [Bmim]OH |
Synthesis of O-2-fluorophenyl Methyl Hydroxylamine Hydrochloride |
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| Wang Wei,Lin Yong,Yu Yangchen,Zhang Shengjian,Zhang Hong.Synthesis of O-2-fluorophenyl Methyl Hydroxylamine Hydrochloride[J].Guangdong Chemical Industry,2012(4):65-66. |
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| Authors: | Wang Wei Lin Yong Yu Yangchen Zhang Shengjian Zhang Hong |
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| Affiliation: | 1.Ningbo Industrial Ivestment Group Co.,Ltd.,Ningbo 315000;2.Ningbo Ocean Chemical New Materials Technology Co.,Ltd.,Ningbo 315203;3.Ningbo Institute of Technology,Zhejiang University,Ningbo 315100,China) |
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| Abstract: | The Paper studies the synthetic process of O-2-fluorophenyl methyl hydroxylamine hydrochloride through O-alkylation and hydrolysis from acetone oxime and 1-（chloromethyl）-2-fluorobenzene.The effect of different conditions,such as reaction temperature,solvents,water on the O-alkylation of acetone oxime with 1-（chloromethyl）-2-fluorobenzene,and the temperature,the concentration of HCl,the material ratio on the hydrolysis reaction are studied.The results shown： the yield of O-alkylation is 92.3 % and hydrolysis was 87.3 %.The product and intermediate were characterized by 1H NMR and 13C NMR. |
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| Keywords: | O-2-fluorophenyl methyl hydroxylamine hydrochloride acetone oxime 1-（chloromethyl）-2-fluorobenzene DMSO [Bmim]OH |
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