壳聚糖烷基化改性及其纳米微球负载扑热息痛的研究

将低分子量壳聚糖经长链烷基在碱性条件下改性制得烷基化壳聚糖衍生物 ,红外光谱研究表明取代反应主要发生在壳聚糖的氨基上 ,透射电镜研究表明该衍生物在水中可自动形成粒径分布在 1 0 0nm左右的纳米微粒。以扑热息痛为模型药物 ,对烷基壳聚糖纳米微球在磷酸缓冲液 (pH =7 4)中体外释放的研究表明 ,在取代度接近的情况下 ,随着烷基链的增长 ,扑热息痛在磷酸缓冲液中的缓释作用得到改善 ,累积达到平衡时的浓度降低。

Study on preparation of cetyl chitosan nanoparticles as paracetamol carrier

Alkyl-chitosan was prepared from chitosan (CS) and alkyl halide under alkaline condition.The infrared (IR) spectra reveal that there is a substitution reaction mainly on the amine groups in CS.TEM shows that this alkyl-chitosan is water-soluble and spontaneously forms nanoparticles with diameter of about 100 nm.The release of paracetamol (used as model drug carried by alkyl-chitosan) was studied in phosphoric acid buffer solution at pH 7.4,and results show that release rate is adjustable by changing the carbon chain length of substitution on CS:the longer the carbon chain is,the slower the release rate is.