基于结晶动力学模型对胞苷酸初晶点的研究

结晶提纯5’-胞苷酸二钠的过程存在明显的不确定性和高度的非线性,其中初晶点无法在线检测,给过程优化策略的实施带来了阻碍。利用单纯形法估计出浓液浓度预测模型的参数,通过浓液浓度的变化预测初晶点范围,并建立了关于流加速率对初晶点的模型。模型结果与实验结果基本吻合,建立的模型有效。

Study on initial crystallization point of cytidine monophosphate based on crystallization kinetics model

The process of crystallizing cytidine-5′monohposphate disodium salt is significant uncertainty and high nonlinearity.The initial crystallization point can not be detected online,which hinders the implementation of process optimization strategies.In this study,the simplex method was used to estimate the parameters of concentration prediction model,predict the scope of initial crystallization point through the changes in concentrations and establish the model for initial crystallization point versus flow rate finally.The results of model fitting are consistent with the experimental results,which indicates that the model is valid.