| 南海红树林内生真菌ZH-3代谢产物研究 |
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| 引用本文： | 杨建香,邱声祥,佘志刚,林永成.南海红树林内生真菌ZH-3代谢产物研究[J].广西化工,2014(2):1-3. |
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| 作者姓名： | 杨建香 邱声祥 佘志刚 林永成 |
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| 作者单位： | [1]中国科学院华南植物园植物资源保护与可持续利用重点实验室,广东广州510650 [2]桂林师范高等专科学校,广西桂林541001 [3]中山大学化学与化学工程学院,广东广州510275 |
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| 基金项目： | 国家自然科学基金资助项目（81373293）,国家863计划和支撑计划项目（201473948）,广西教育厅科研项目（201204LX497） |
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| 摘 要： | 研究南海红树林内生真菌ZH-3的代谢产物。采用反复硅胶柱色谱法、Sephadex LH-20凝胶色谱法等进行分离纯化，并通过理化常数测定和光谱分析鉴定其化学结构。从南海红树林内生真菌ZH-3的菌体中分离得到4个代谢产物，经波谱解析，分别为2-（3-chloro-2,6-dihydroxy-4-methylbenzoyl）-5-hydroxy-3-methoxybenzoate.（1），3＇-dihydroxy-5,5＇-dimethyldiphenyl ether（2），7,8-二甲基苯并g]蝶啶-2,4（1H,3H）-二酮（3），5-o-methylbostrycoidin （4）。初步药理活性显示化合物1对人体肝癌细胞hepG2抑制的IC50值为25μg·mL-1。所有化合物均首次从南海红树林内生真菌ZH-3中分离得到。
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| 关 键 词： | 红树林 内生真菌 代谢产物 |
Metabolites of Mangrove Endophytic Fungus ZH-3 from South China Sea |
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| YANG Jian-xiang,QIU Sheng-xiang,SHE Zhi-gang,LIN Yong-cheng.Metabolites of Mangrove Endophytic Fungus ZH-3 from South China Sea[J].Guangxi Chemical Industry,2014(2):1-3. |
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| Authors: | YANG Jian-xiang QIU Sheng-xiang SHE Zhi-gang LIN Yong-cheng |
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| Affiliation: | 1. Key Laboratory of Plant Resources Conservation and Sustainable Utilization , South China Botanical Garden, Chinese Academyof Sciences, Guangzhou 510650, China; 2. Department of Chemistry and Engineering, Guilin Normal College, Guilin 541002, China;3. School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China) |
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| Abstract: | Secondary metabolites of mangrove endophytic fungus No. ZH-3 from South China sea were studied. The compounds were isolated by column chromatography and identified on the basic of physic-chemical constants and spectral analysis. Four metabolites were obtained and elucidated as 2-（3-chloro-2,6-dihydroxy-4-methylbenzoyl）-5-hydroxy-3-methoxybenzoate. （1）,3,3’-dihydroxy-5,5’-dimethyldiphenylether（2）, 7,8-dimethylbenzog]pteridine-2,4（1H,3H）-dione （3）, 5-o-methylbostrycoidin （4）. In the preliminary bioassay, 1 show inhibittory activity on the hepG2 cell line with IC50values of 25μg/mL. The four metabolites were obtained from endophytic fungus No. ZH-3 for the ifrst time. |
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| Keywords: | mangrove endophytic fungus metabolites |
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