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| 2-氨基丙醇的合成研究 | |
| 引用本文： | 王伟强,顾海宁,李小玲.2-氨基丙醇的合成研究[J].浙江化工,2010,41(1):15-17. |
| 作者姓名： | 王伟强 顾海宁 李小玲 |
| 作者单位： | 1. 浙江京新药业股份有限公司,浙江,新昌,312500 2. 浙江大学分析测试中心,浙江,杭州,310028 3. 杭州师范大学,材化学院,浙江,杭州,310036;杭州广林生物医药有限公司,浙江,杭州,310028 |
| 基金项目： | 国家支撑计划项目，浙江省科技计划项目 |
| 摘 要： | 以环氧丙烷为原料,开环生成α-氯丙醇和β-氯丙醇,β-氯丙醇再经氨解制得目标产物2-氨基丙醇;α-氯丙醇经皂化反应生成起始原料环氧丙烷进入循环反应。本合成工艺反应简单,操作方便,成本低;副产物可回收套用,原子经济性高,工业化前景良好。 |
| 关 键 词： | 氨基丙醇 β-氯丙醇 环氧丙烷 喹诺酮 合成 |
Study on Synthesis of 2-Aminopropanol |
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| WANG Wei-qiang,GO Hai-ning,LI Xiao-ling.Study on Synthesis of 2-Aminopropanol[J].Zhejiang Chemical Industry,2010,41(1):15-17. | |
| Authors: | WANG Wei-qiang GO Hai-ning LI Xiao-ling |
| Affiliation: | WANG Wei-qiang1,GU Hai-ning2,LI Xiao-ling3,4(1.Zhejiang Jingxin Pharmaceutical Co.Ltd.,Xinchang 312500,China,2.Center of Analysis & Measurement of Zhejiang University,Hangzhou 310028,3.College of Material,Chemistry , Chemical Engineering,Hangzhou Normal University,Hangzhou 310036,4.Hangzhou Great froest Biomedical Co.Ltd.,China) |
| Abstract: | 2-Aminopropanol was prepared from Propylene oxide, via ring-opening and aminolysis of α- chloropropanol, α-chloropropanol, another product of ring-opening reaction, was circulated to propylene oxide as starting material by saponification. This process has many advantages, such as simple procedure, low cost, high atom economy and less pollution, so it is suitable for industrial production. |
| Keywords: | 2-aminopropanol α-chloropropanol propylene oxide quinolone synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |