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| 头孢喹咪的合成研究 | |
| 引用本文： | 顾海宁,李小玲,汪劲松.头孢喹咪的合成研究[J].浙江化工,2009,40(12):6-8. |
| 作者姓名： | 顾海宁 李小玲 汪劲松 |
| 作者单位： | 1. 浙江大学分析测试中心,浙江,杭州,310028 2. 杭州师范大学材料与化学化工学院,浙江,杭州,310036;杭州广林生物医药有限公司,浙江,杭州,310028 3. 杭州广林生物医药有限公司,浙江,杭州,310028 |
| 摘 要： | 介绍了以头孢噻肟为起始原料，在氮气保护及三甲基碘硅烷的存在下，与自制的5，6，7，8-四氢喹啉发生取代反应．反应结束后加入H2SO4、乙醇和水的混合溶液，使头孢喹咪成碘酸盐分离出来．再经离子交换成硫酸盐制得头孢喹咪的方法。该方法不仅降低了5，6，7，8-四氢喹啉和三甲基碘硅烷的用量．而且所用原料廉价易得，成本低，适合工业化生产。 |
| 关 键 词： | 头孢喹咪 头孢噻肟 5 6 7 8-四氢喹啉 三甲基碘硅烷 |
Study on Synthesis of Cefquinome |
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| GU Hai-ning,LI Xiao-ling,WANG Jin-song.Study on Synthesis of Cefquinome[J].Zhejiang Chemical Industry,2009,40(12):6-8. | |
| Authors: | GU Hai-ning LI Xiao-ling WANG Jin-song |
| Affiliation: | GU Hai-ning , LI Xiao-ling , WANG Jin-song (1. Center of Analysis ＆ Measurement of Zhejiang University, Hangzhou 310028,China;2.College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036,China; 3.Hangzhou Great froest Biomedical Co. Ltd., Hangzhou 310028,China) |
| Abstract: | Cefquinome was prepared from cefotaxime, via substitution with 5,6,7,8-tetrahydroquinoline under the effect of N2 and trimethyliodosilane, then treated with a mixture of H2SO4, ethanol and water to obtain cefquinome hydroiodide, and finally salt exchanged with anion exchange resin. This process has many advantages, such as easily obtained materials, and low cost, so it is suitable for industrial production. |
| Keywords: | eefquinome cefotaxime 5 6 7 8-tetrahydroquinoline trimethyliodosilane |
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