| MCM-41的制备及用于吡拉西坦缓释性能研究 |
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| 引用本文： | 刘治刚,王建刚,于世华,金刚,高艳.MCM-41的制备及用于吡拉西坦缓释性能研究[J].化工科技,2013(6):42-44. |
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| 作者姓名： | 刘治刚 王建刚 于世华 金刚 高艳 |
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| 作者单位： | [1]吉林化工学院分析测试中心,吉林吉林132022 [2]吉林化工学院化学与制药工程学院,吉林吉林132022 |
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| 摘 要： | 以十六烷基三甲基溴化铵（CTAB）为模板剂,正硅酸乙酯（TEOS）为硅源,合成MCM-41分子筛.以其做载体,吡拉西坦为模型药物,研究了吡拉西坦在MCM-41分子筛的负载与释放性能.并通过扫描电子显微镜（SEM）、粉末X-射线衍射（XRD）和傅立叶变换红外光谱（FT-IR）等方法对MCM-41分子筛以及负载吡拉西坦后的样品进行表征.研究了吡拉西坦的负载量及释放性能,定时检测了制备药物在模拟体液中的释放过程,从而确定以MCM-41作为吡拉西坦缓释载体的可能性.
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| 关 键 词： | MCM-41 药物载体 缓释 吡拉西坦 |
preparation of MCM-41 and application of piracetam used for sustained release |
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| Liu Zhigang,Wang Jiangang,Yu Shihua,Jin Gang,Gao Yan.preparation of MCM-41 and application of piracetam used for sustained release[J].Science & Technology In Chemical Industry,2013(6):42-44. |
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| Authors: | Liu Zhigang Wang Jiangang Yu Shihua Jin Gang Gao Yan |
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| Affiliation: | 1. Analysis and Test Center, Jilin Institute of Chemical Technology, Jilin 132022, China; 2. College of Chemical Pharmaceutical Engineering, J ilin Institute of Chemical Technology, J ilin 132002 ,China) |
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| Abstract: | Abstract： Mesoporous molecular sieves MCM-41 are synthesized by conventional hydrothermal process using tetraethylortho silicate （TEOS） as silicon source and cetyl trimethyl ammonium bromide （CTAB） as a template agent. Piracetam is assembled into the port-hole of mesoporous molecular sieve MCM-41 by the impregnation. Adsorption of the mesoporous molecular sieve by X-ray diffraction （XRD） ,scanning electron microscopy （SEM）,infrared spectra （IR） had been used to characterize the molecular sieve adsorption, We have studied the loading and release properties of piracetam, and the timely detection of the release process for the preparation of the drug in simulated body fluid, so as to determine the possibility of using MCM-41 as piracetam sustained-release carrier. |
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| Keywords: | MCM-41 Drug carries Sustained-release Piracetam |
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