α-羟基环己基苯基甲酮合成工艺研究进展

α-羟基环己基苯基甲酮（光引发剂184）是一种高效光引发剂，因其引发效率高、稳定性好、耐黄变等优势，在电子、涂料、印刷等领域得到广泛的应用。本文根据起始原料不同对α-羟基环己基苯基甲酮的合成方法进行分类，并归纳了不同合成方法的特点。重点介绍了以环己基苯基甲酮为中间体的合成工艺以及其他合成α-羟基环己基苯基甲酮的工艺路线。目前，工业上最常用的Friedel-Crafts酰基化法合成光引发剂184的工艺路线，因为产生的三废多且有毒有害，不符合绿色化工的要求，而将逐渐被淘汰。以格氏反应法合成环己基苯基甲酮继而再合成α-羟基环己基苯基甲酮的工艺路线，因其收率高、污染少等优点而有望成为合成α-羟基环己基苯基甲酮的重要发展方向之一。最后，指出了α-羟基环己基苯基甲酮合成工艺研究的趋势。

Research progress in the synthesis of α-hydroxycyclohexyl phenyl ketone

α-hydroxycyclohexyl phenyl ketone (Irgacure184) is a type of high-efficiency photoinitiator, which is widely applied in electronics, coatings, printing, etc. This paper classifies its synthesis methods according to different starting materials and summarizes the characteristics of each method. Meanwhile, this paper mainly introduces the process of using cyclohexyl phenyl ketone as raw material and other routes to synthesize α-hydroxycyclohexyl phenyl ketone. At present, the Friedel-Crafts acylation method for synthesizing α-hydroxycyclohexyl phenyl ketone is most commonly used. However, because of the wastes and the strong toxicity, this method does not meet the requirements of green chemistry and will gradually be eliminated. Among all the synthesis routes, using the Grignard reaction to obtain α-hydroxycyclohexyl phenyl ketone is expected to be one of the most considerable directions owing to its high yield and environmental benign nature. At the end, the trend of researches on synthesizing α-hydroxycyclohexyl phenyl ketone is pointed out.